Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ5 | P48544 | 1/20 | 0.62 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | PKM | P14618 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.57 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.54 |
| ▸ | STAT3 | P40763 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | CCKBR | P32239 | 1/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29623328 | 0.90 | MAPT (0.61) | MAPTLMNAPKMMEN1KMT2A | |
| SCHEMBL23175238 | 0.90 | MAPT (0.61) | MAPTLMNAPKMMEN1KMT2A | |
| SCHEMBL27332104 | 0.86 | MEN1 (0.61) | MAPTLMNAPKMMEN1KMT2A | |
| SCHEMBL11189753 | 0.86 | HRH3 (0.67) | MAPTLMNAPKMMEN1KMT2A | |
| SCHEMBL7807900 | 0.85 | HRH3 (0.67) | MAPTLMNAMEN1KMT2AHRH3 | |
| SCHEMBL31218207 | 0.85 | HRH3 (0.67) | MAPTLMNAMEN1KMT2AHRH3 | |
| SCHEMBL18229457 | 0.84 | MAPT (0.57) | KCNJ5KCNJ3MAPTLMNAPKM | |
| SCHEMBL18229449 | 0.84 | LMNA (0.57) | MAPTLMNAPKMHRH3 | |
| SCHEMBL28885924 | 0.82 | KMT2A (0.68) | MAPTLMNAPKMMEN1KMT2A | |
| SCHEMBL29936534 | 0.82 | MEN1 (0.57) | MAPTLMNAPKMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107149602-B | Application of indole compounds and derivatives thereof in preparation of anti-HIV drugs | 中国医学科学院药物研究所 | 2020-10-09 | — | — | CN | disclosed |
| CN-107149603-B | Application of indole compounds and derivatives thereof in preparation of anti-influenza virus drugs | 中国医学科学院药物研究所 | 2020-07-14 | — | — | CN | disclosed |
| CN-107176921-B | Indole compounds with antiviral activity in isatis root and derivatives thereof | 中国医学科学院药物研究所 | 2020-03-31 | — | — | CN | disclosed |