Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 7/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28385548 | 0.92 | BTK (0.38) | JAK3EGFRBTKITK | |
| SCHEMBL28385472 | 0.92 | BTK (0.42) | JAK3MAPK3EGFRBTKITK | |
| SCHEMBL28387170 | 0.91 | JAK3 (0.37) | JAK3EGFRBTKITK | |
| SCHEMBL28383465 | 0.90 | BTK (0.42) | JAK3JAK2JAK1TYK2EGFR | |
| SCHEMBL28382401 | 0.88 | FGFR1 (0.42) | JAK3JAK2JAK1TYK2EGFR | |
| SCHEMBL28384393 | 0.87 | SLC6A3 (0.45) | — | |
| SCHEMBL28383332 | 0.87 | — | — | |
| SCHEMBL28384362 | 0.85 | EGFR (0.45) | JAK3JAK2MAPK3EGFRBTK | |
| SCHEMBL28387194 | 0.84 | FGFR1 (0.45) | EGFRBTKITK | |
| SCHEMBL28387958 | 0.84 | EGFR (0.42) | JAK3JAK2JAK1TYK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105682661-B | Certain chemical entities, compositions, and methods | 润新生物公司 | 2020-03-27 | — | — | CN | claimed |
| CN-109851617-B | Chemical entities, compositions, and methods | 润新生物公司 | 2022-08-16 | — | — | CN | disclosed |
| CN-111285813-A | Chemical entities, compositions, and methods | 润新生物公司 | 2020-06-16 | — | — | CN | disclosed |
| CN-105682661-B | Certain chemical entities, compositions, and methods | 润新生物公司 | 2020-03-27 | — | — | CN | disclosed |