Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.45 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | BLK | P51451 | 1/20 | 0.42 |
| ▸ | BMX | P51813 | 1/20 | 0.42 |
| ▸ | CTSC | P53634 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | DCLK3 | Q9C098 | 1/20 | 0.42 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.42 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28414763 | 0.97 | EGFR (0.43) | EGFRERBB4MAPK3ERBB2ERBB3 | |
| SCHEMBL28388785 | 0.93 | EGFR (0.43) | EGFRJAK3 | |
| SCHEMBL28394117 | 0.92 | EGFR (0.43) | EGFRJAK3 | |
| SCHEMBL28412163 | 0.91 | EGFR (0.42) | EGFRJAK3 | |
| SCHEMBL28422007 | 0.90 | EGFR (0.41) | EGFRJAK3 | |
| SCHEMBL28387179 | 0.90 | EGFR (0.49) | EGFRERBB4ERBB2ERBB3JAK3 | |
| SCHEMBL28384393 | 0.89 | SLC6A3 (0.45) | — | |
| SCHEMBL28384151 | 0.88 | ALK (0.47) | EGFRJAK3ALK | |
| SCHEMBL28418732 | 0.86 | EGFR (0.41) | EGFRJAK3JAK2 | |
| SCHEMBL28383333 | 0.85 | JAK3 (0.39) | EGFRMAPK3JAK3JAK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105682661-B | Certain chemical entities, compositions, and methods | 润新生物公司 | 2020-03-27 | — | — | CN | claimed |
| CN-109851617-B | Chemical entities, compositions, and methods | 润新生物公司 | 2022-08-16 | — | — | CN | disclosed |
| CN-111285813-A | Chemical entities, compositions, and methods | 润新生物公司 | 2020-06-16 | — | — | CN | disclosed |
| CN-105682661-B | Certain chemical entities, compositions, and methods | 润新生物公司 | 2020-03-27 | — | — | CN | disclosed |