Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 5/20 | 0.53 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28383371 | 0.86 | PIM1 (0.55) | PIM1PIM3NPSR1ALDH1A1TSHR | |
| SCHEMBL28383357 | 0.84 | CHEK1 (0.65) | PIM1PIM3CHEK1 | |
| SCHEMBL15071641 | 0.84 | PIM1 (0.72) | PIM1PIM3NPSR1ALDH1A1TSHR | |
| SCHEMBL28382785 | 0.83 | CHEK1 (0.66) | CHEK1 | |
| SCHEMBL20598523 | 0.83 | NTRK1 (0.56) | PIM1PIM3KMT2AMAPTMEN1 | |
| SCHEMBL20598729 | 0.82 | CSF1R (0.49) | PIM1PIM3ALDH1A1TSHRKMT2A | |
| SCHEMBL28383358 | 0.79 | CHEK1 (0.69) | CHEK1 | |
| SCHEMBL20598394 | 0.79 | PIM1 (0.53) | PIM1PIM3TSHRPOLBCYP1A2 | |
| SCHEMBL28379784 | 0.78 | MAPK10 (0.74) | NPSR1ALDH1A1TSHRPOLBCYP1A2 | |
| SCHEMBL28378617 | 0.78 | PIM1 (0.41) | PIM1PIM3NPSR1TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032642-B | Kinase inhibitors and methods of making and using the same | 里格尔药品股份有限公司 | 2023-07-18 | — | — | CN | disclosed |
| CN-111032642-A | Kinase inhibitors and methods of making and using | 里格尔药品股份有限公司 | 2020-04-17 | — | — | CN | disclosed |