Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 7/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | TSHR | P16473 | 3/20 | 0.74 |
| ▸ | HPGD | P15428 | 2/20 | 0.74 |
| ▸ | CSF1R | P07333 | 2/20 | 0.72 |
| ▸ | HTT | P42858 | 4/20 | 0.70 |
| ▸ | GAA | P10253 | 2/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | ATM | Q13315 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 5/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13147762 | 0.84 | CSF1R (1.00) | MAPK10ALDH1A1TSHRHPGDCSF1R | |
| SCHEMBL13167004 | 0.83 | ALDH1A1 (1.00) | MAPK10ALDH1A1TSHRHPGDCSF1R | |
| SCHEMBL20598829 | 0.81 | NPC1 (0.72) | MAPK10ALDH1A1TSHRHPGDCSF1R | |
| SCHEMBL20598140 | 0.81 | ALDH1A1 (0.67) | MAPK10ALDH1A1TSHRHPGDCSF1R | |
| SCHEMBL28383371 | 0.80 | PIM1 (0.55) | MAPK10ALDH1A1TSHRHPGDCSF1R | |
| SCHEMBL29033220 | 0.79 | HPGD (0.52) | MAPK10ALDH1A1TSHRHPGDCSF1R | |
| SCHEMBL20598769 | 0.78 | ALDH1A1 (0.61) | MAPK10ALDH1A1TSHRHPGDCSF1R | |
| SCHEMBL28383374 | 0.78 | PIM1 (0.53) | MAPK10ALDH1A1TSHRHPGDCSF1R | |
| SCHEMBL28384221 | 0.78 | HPGD (0.51) | MAPK10ALDH1A1TSHRHPGDCSF1R | |
| SCHEMBL20598518 | 0.77 | NPC1 (0.66) | MAPK10ALDH1A1TSHRHPGDCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032642-B | Kinase inhibitors and methods of making and using the same | 里格尔药品股份有限公司 | 2023-07-18 | — | — | CN | disclosed |
| CN-111032642-A | Kinase inhibitors and methods of making and using | 里格尔药品股份有限公司 | 2020-04-17 | — | — | CN | disclosed |