Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 12/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28382394 | 0.88 | MAPK10 (0.46) | PIM1PIM3TSHRPOLBATM | |
| SCHEMBL28378686 | 0.87 | CHEK1 (0.55) | CHEK1 | |
| SCHEMBL28378703 | 0.81 | TSHR (0.59) | TSHRPOLBATMMAPK10MAPK8 | |
| SCHEMBL28383374 | 0.78 | PIM1 (0.53) | PIM1PIM3TSHRPOLBATM | |
| SCHEMBL29033319 | 0.76 | HPGD (0.42) | TSHRPOLBATMMAPK10KDM4E | |
| SCHEMBL15071641 | 0.72 | PIM1 (0.72) | PIM1PIM3TSHRCHEK1NPSR1 | |
| SCHEMBL28383357 | 0.68 | CHEK1 (0.65) | PIM1PIM3CHEK1 | |
| SCHEMBL20598523 | 0.68 | NTRK1 (0.56) | PIM1PIM3 | |
| SCHEMBL20598729 | 0.67 | CSF1R (0.49) | PIM1PIM3TSHRKDM4E | |
| SCHEMBL10184985 | 0.67 | PIM2 (0.59) | PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032642-B | Kinase inhibitors and methods of making and using the same | 里格尔药品股份有限公司 | 2023-07-18 | — | — | CN | disclosed |
| CN-111032642-A | Kinase inhibitors and methods of making and using | 里格尔药品股份有限公司 | 2020-04-17 | — | — | CN | disclosed |