Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 2/20 | 0.46 |
| ▸ | JUN | P05412 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | ERBB3 | P21860 | 4/20 | 0.40 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 2/20 | 0.38 |
| ▸ | CCND1 | P24385 | 2/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28388186 | 0.94 | TTK (0.46) | TTKJUNMAPK8MAPK10ERBB3 | |
| SCHEMBL28382474 | 0.88 | TTK (0.54) | TTKJUNMAPK8MAPK10ERBB3 | |
| SCHEMBL28887734 | 0.88 | TTK (0.53) | TTKJUNMAPK8MAPK10ERBB3 | |
| SCHEMBL29847697 | 0.88 | JUN (0.51) | TTKJUNMAPK8MAPK10ERBB3 | |
| SCHEMBL16513629 | 0.88 | JUN (0.51) | TTKJUNMAPK8MAPK10ERBB3 | |
| SCHEMBL28388793 | 0.87 | PIM1 (0.39) | ERBB3EGFRPIM1PIM2PIK3CD | |
| SCHEMBL28388525 | 0.87 | TTK (0.47) | TTKJUNMAPK8MAPK10ERBB3 | |
| SCHEMBL28384112 | 0.87 | TTK (0.46) | TTKJUNMAPK8MAPK10ERBB3 | |
| SCHEMBL16513785 | 0.85 | MAPK10 (0.45) | TTKJUNMAPK8MAPK10ERBB3 | |
| SCHEMBL29848062 | 0.85 | MAPK10 (0.45) | TTKJUNMAPK8MAPK10ERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105682661-B | Certain chemical entities, compositions, and methods | 润新生物公司 | 2020-03-27 | — | — | CN | claimed |
| CN-109851617-B | Chemical entities, compositions, and methods | 润新生物公司 | 2022-08-16 | — | — | CN | disclosed |
| CN-111285813-A | Chemical entities, compositions, and methods | 润新生物公司 | 2020-06-16 | — | — | CN | disclosed |
| CN-105682661-B | Certain chemical entities, compositions, and methods | 润新生物公司 | 2020-03-27 | — | — | CN | disclosed |