Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 6/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | JUN | P05412 | 5/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.37 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.36 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28384112 | 0.89 | TTK (0.46) | TTKJUNMAPK8MAPK10IGF1R | |
| SCHEMBL28382474 | 0.89 | TTK (0.54) | TTKJUNMAPK8MAPK10IGF1R | |
| SCHEMBL29847920 | 0.87 | JUN (0.48) | TTKJUNMAPK8MAPK10IGF1R | |
| SCHEMBL16823087 | 0.87 | JUN (0.48) | TTKJUNMAPK8MAPK10IGF1R | |
| SCHEMBL28887734 | 0.87 | TTK (0.53) | TTKJUNMAPK8MAPK10SCN5A | |
| SCHEMBL28388501 | 0.87 | TGFBR1 (0.40) | TGFBR1TDP1SCN5ASCN9ASMN1; SMN2 | |
| SCHEMBL28388186 | 0.87 | TTK (0.46) | TTKJUNMAPK8MAPK10IGF1R | |
| SCHEMBL28384226 | 0.87 | TTK (0.46) | TTKJUNMAPK8MAPK10IGF1R | |
| SCHEMBL16822852 | 0.85 | FGFR2 (0.42) | TTKTGFBR1JUNMAPK8MAPK10 | |
| SCHEMBL29847963 | 0.85 | FGFR2 (0.42) | TTKTGFBR1JUNMAPK8MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105682661-B | Certain chemical entities, compositions, and methods | 润新生物公司 | 2020-03-27 | — | — | CN | claimed |
| CN-109851617-B | Chemical entities, compositions, and methods | 润新生物公司 | 2022-08-16 | — | — | CN | disclosed |
| CN-111285813-A | Chemical entities, compositions, and methods | 润新生物公司 | 2020-06-16 | — | — | CN | disclosed |
| CN-105682661-B | Certain chemical entities, compositions, and methods | 润新生物公司 | 2020-03-27 | — | — | CN | disclosed |