SCHEMBL28387243

SCHEMBL28387243

Nc1nc(SCCC(F)(F)F)nc2[nH]cnc12

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KDR P35968 1/20 0.32
AURKB Q96GD4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28502426 0.83
SCHEMBL29386248 0.81 ALDH1A1 (0.41) KDRAURKB
SCHEMBL3960621 0.79 SMN1; SMN2 (0.45)
SCHEMBL4408534 0.78 HSP90AA1 (0.39) KDRAURKB
SCHEMBL5144923 0.78 KDM4E (0.47)
SCHEMBL4068517 0.78 METAP2 (0.38) KDRAURKB
SCHEMBL24980489 0.77 APEX1 (0.42) KDRAURKB
SCHEMBL27157678 0.77 KDM4E (0.49)
SCHEMBL27157684 0.77 ABCB1 (0.55)
SCHEMBL17620259 0.76 P2RY12 (0.39)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107973798-B 2- [ (3,3, 3-trifluoropropyl) thio ] -6-amino-9H-purine and its preparation 上海医药工业研究院 2020-04-24 CN claimed
CN-107973832-B 6-N- [2- (methylthio) ethyl ] -2- [ (3,3, 3-trifluoropropyl) thio ] adenosine 上海医药工业研究院 2021-11-12 CN disclosed
CN-107973798-B 2- [ (3,3, 3-trifluoropropyl) thio ] -6-amino-9H-purine and its preparation 上海医药工业研究院 2020-04-24 CN disclosed
CN-107973798-B 2- [ (3,3, 3-trifluoropropyl) thio ] -6-amino-9H-purine and its preparation 上海医药工业研究院 2020-04-24 CN disclosed
CN-107973798-B 2- [ (3,3, 3-trifluoropropyl) thio ] -6-amino-9H-purine and its preparation 上海医药工业研究院 2020-04-24 CN disclosed