Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.31 |
| ▸ | CCR7 | P32248 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3962781 | 0.86 | RAB9A (0.43) | ALDH1A1CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL29386248 | 0.84 | ALDH1A1 (0.41) | ALDH1A1LMNAKDM4EHTTHSD17B10 | |
| SCHEMBL3960621 | 0.82 | SMN1; SMN2 (0.45) | ALDH1A1LMNAKDM4EHTTHSD17B10 | |
| SCHEMBL4408534 | 0.81 | HSP90AA1 (0.39) | ALDH1A1LMNAKDM4EHTTHSD17B10 | |
| SCHEMBL5144923 | 0.81 | KDM4E (0.47) | ALDH1A1LMNAKDM4EHTTHSD17B10 | |
| SCHEMBL27157678 | 0.80 | KDM4E (0.49) | ALDH1A1LMNAKDM4EHTTHSD17B10 | |
| SCHEMBL4058424 | 0.80 | CDK1 (0.38) | ALDH1A1CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL756296 | 0.78 | HASPIN (0.33) | ALDH1A1KDM4ECDK1CCNB1CCNA2 | |
| SCHEMBL28387243 | 0.78 | KDR (0.32) | KDRAURKB | |
| SCHEMBL24980489 | 0.77 | APEX1 (0.42) | ALDH1A1SMN1; SMN2NPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034386-A1 | DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009034386-A1 | DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | disclosed |