Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 6/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | WNT1 | P04628 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 2/20 | 0.31 |
| ▸ | RARA | P10276 | 1/20 | 0.31 |
| ▸ | RARB | P10826 | 1/20 | 0.31 |
| ▸ | RARG | P13631 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2840973 | 0.76 | PIN1 (0.40) | CTSKPIN1NOTUMRIPK1ABL1 | |
| SCHEMBL2729920 | 0.76 | PIN1 (0.40) | CTSKPIN1NOTUMRIPK1ABL1 | |
| SCHEMBL2841496 | 0.75 | CTSK (0.36) | CTSKPIN1NOTUMABL1DYRK1A | |
| SCHEMBL2730660 | 0.75 | PIN1 (0.42) | CTSKPIN1NOTUMRIPK1ABL1 | |
| SCHEMBL2842131 | 0.75 | PIN1 (0.42) | CTSKPIN1NOTUMRIPK1ABL1 | |
| SCHEMBL2728040 | 0.75 | PIN1 (0.42) | CTSKPIN1NOTUMRIPK1ABL1 | |
| SCHEMBL2839982 | 0.74 | CTSK (0.37) | CTSKNOTUMRIPK1ABL1DYRK1A | |
| SCHEMBL2840966 | 0.74 | PIN1 (0.36) | CTSKPIN1NOTUMABL1DYRK1A | |
| SCHEMBL2839632 | 0.74 | CTSK (0.37) | CTSKPIN1NOTUMRIPK1ABL1 | |
| SCHEMBL2839634 | 0.74 | CTSK (0.37) | CTSKPIN1NOTUMRIPK1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195328-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Incorporated (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009023193-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2009-02-19 | — | — | WO | disclosed |