Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.57 |
| ▸ | GSK3A | P49840 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | MGLL | Q99685 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | CCR3 | P51677 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21047654 | 0.85 | SLC6A3 (0.56) | SLC6A3SIGMAR1HTR1ADRD2L3MBTL1 | |
| SCHEMBL26106505 | 0.82 | SLC6A3 (0.62) | SLC6A3SIGMAR1HTR1ADRD2L3MBTL1 | |
| SCHEMBL1585063 | 0.81 | SLC6A3 (0.61) | SLC6A3SIGMAR1HTR1ADRD2MAOA | |
| Hydrochloric Acid SCHEMBL27638849 | 0.81 | SLC6A3 (0.61) | SLC6A3SIGMAR1L3MBTL1 | |
| SCHEMBL486687 | 0.80 | SLC6A3 (0.66) | SLC6A3SIGMAR1MEN1KMT2AHTR1A | |
| SCHEMBL8108965 | 0.80 | SLC6A3 (0.66) | SLC6A3SIGMAR1MEN1KMT2AHTR1A | |
| Hydrochloric Acid SCHEMBL486705 | 0.79 | SLC6A3 (0.63) | SLC6A3SIGMAR1HTR1ADRD2ACHE | |
| Iodide SCHEMBL195620 | 0.79 | SLC6A3 (0.63) | SLC6A3SIGMAR1MEN1KMT2AHTR1A | |
| SCHEMBL2438031 | 0.78 | SIGMAR1 (0.60) | SIGMAR1GSK3AGSK3BMGLLGAA | |
| SCHEMBL6897743 | 0.78 | SLC6A3 (0.68) | SLC6A3SIGMAR1HTR1ADRD2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111689959-B | Heterocyclic compounds as FGFR4 inhibitors | 石药集团中奇制药技术（石家庄）有限公司 | 2022-04-01 | — | — | CN | disclosed |
| CN-111689959-A | Heterocyclic compounds as FGFR4 inhibitors | 石药集团中奇制药技术（石家庄）有限公司 | 2020-09-22 | — | — | CN | disclosed |
| CN-109153678-B | Heterocyclic compounds as FGFR4 inhibitors | 石药集团中奇制药技术（石家庄）有限公司 | 2020-04-14 | — | — | CN | disclosed |