Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | BCR | P11274 | 2/20 | 0.46 |
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26987208 | 0.89 | HPGD (0.70) | HPGDCA12CA1CA2CA7 | |
| Ethylene SCHEMBL8378361 | 0.86 | HPGD (0.66) | HPGDCA12CA1CA2CA7 | |
| SCHEMBL694171 | 0.85 | HPGD (0.63) | HPGDCA12CA1CA2CA7 | |
| SCHEMBL6558877 | 0.83 | CA1 (0.51) | HPGDCA12CA1CA2CA7 | |
| SCHEMBL7469385 | 0.82 | HPGD (0.56) | HPGDLMNAALDH1A1MTHFD2 | |
| SCHEMBL7047272 | 0.80 | HPGD (0.63) | HPGDPOLBLMNAALDH1A1KMT2A | |
| SCHEMBL24120195 | 0.79 | HPGD (0.61) | HPGDPOLBL3MBTL3L3MBTL1LMNA | |
| SCHEMBL7380773 | 0.79 | ALDH1A1 (0.52) | CA1CA2L3MBTL1GPR183ALDH1A1 | |
| SCHEMBL644199 | 0.76 | HPGD (0.92) | HPGDCA12CA1CA2CA7 | |
| SCHEMBL971083 | 0.76 | HPGD (1.00) | HPGDCA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111116585-B | Compound with c-MET kinase inhibitory activity, preparation method, composition and application | 北京鑫开元医药科技有限公司 | 2021-02-05 | — | — | CN | disclosed |
| CN-111116585-A | Compound with c-MET kinase inhibitory activity, preparation method, composition and application | 北京鑫开元医药科技有限公司 | 2020-05-08 | — | — | CN | disclosed |