Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7047272 | 0.90 | HPGD (0.63) | HPGDALDH1A1LMNASMN1; SMN2TSHR | |
| SCHEMBL8538640 | 0.89 | HPGD (0.62) | HPGDSIGMAR1ALDH1A1ACHELMNA | |
| SCHEMBL263534 | 0.89 | HPGD (0.66) | HPGDSIGMAR1ALDH1A1ACHEUSP2 | |
| SCHEMBL11605873 | 0.84 | HPGD (0.59) | HPGDSIGMAR1ALDH1A1ACHEUSP2 | |
| SCHEMBL6474754 | 0.82 | HPGD (0.68) | HPGDSIGMAR1ALDH1A1ACHELMNA | |
| SCHEMBL6558877 | 0.82 | CA1 (0.51) | HPGDALDH1A1LMNASMN1; SMN2MTHFD2 | |
| SCHEMBL28396337 | 0.82 | HPGD (0.61) | HPGDALDH1A1LMNAMTHFD2 | |
| SCHEMBL22111679 | 0.81 | HPGD (0.55) | HPGDSIGMAR1ALDH1A1ACHEUSP2 | |
| SCHEMBL4279383 | 0.80 | HPGD (0.73) | HPGDALDH1A1LMNACYP2C9SMN1; SMN2 | |
| SCHEMBL30277860 | 0.80 | HPGD (0.73) | HPGDALDH1A1LMNACYP2C9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0936912-A4 | INHIBITORS OF CYSTEINE PROTEASE | SMITHKLINE BEECHAM CORP (US) | 1999-10-13 | — | — | EP | claimed |
| EP-0936912-A1 | INHIBITORS OF CYSTEINE PROTEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-25 | — | — | EP | claimed |
| WO-1998005336-A1 | INHIBITORS OF CYSTEINE PROTEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-12 | — | — | WO | claimed |