Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | EEF2K | O00418 | 1/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28404275 | 0.86 | GBA1 (0.61) | MAPTALDH1A1GBA1MEN1KMT2A | |
| SCHEMBL8728412 | 0.81 | KDM4E (0.46) | MAPTALDH1A1GRIA4EEF2KSLC1A2 | |
| SCHEMBL28890019 | 0.80 | GRIA4 (0.43) | MAPTALDH1A1GRIA4 | |
| SCHEMBL29182088 | 0.77 | ESRRG (0.56) | MAPTNPC1RAB9ATP53TDP1 | |
| SCHEMBL29555017 | 0.76 | MAPT (0.52) | MAPTALDH1A1GRIA4CYP2C19GBA1 | |
| SCHEMBL28398275 | 0.74 | EEF2K (0.80) | MAPTALDH1A1EEF2KSLC1A2NPC1 | |
| SCHEMBL12982899 | 0.73 | KEAP1 (0.69) | MAPTALDH1A1CYP2C19KEAP1HDAC3 | |
| SCHEMBL5051651 | 0.72 | AKR1C3 (0.47) | GRIA4 | |
| SCHEMBL11121354 | 0.72 | ALDH1A1 (0.53) | ALDH1A1GBA1TP53GAA | |
| SCHEMBL1925462 | 0.71 | POLB (0.49) | MAPTALDH1A1CYP2C19GBA1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107903185-B | Preparation and application of novel eEF2K inhibitor | 四川大学 | 2020-05-26 | — | — | CN | disclosed |