Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | EBP | Q15125 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3647529 | 1.00 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1PDK1PKMMAPK1 | |
| SCHEMBL294985 | 1.00 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1PDK1PKMMAPK1 | |
| SCHEMBL38657611 | 1.00 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1PDK1PKMMAPK1 | |
| SCHEMBL30997338 | 0.80 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1 | |
| SCHEMBL6247128 | 0.76 | ALDH1A1 (0.42) | ALDH1A1L3MBTL1PDK1PKMMAPK1 | |
| SCHEMBL6628037 | 0.75 | — | — | |
| SCHEMBL16939953 | 0.75 | — | — | |
| SCHEMBL11826634 | 0.74 | PDK1 (0.41) | ALDH1A1L3MBTL1PDK1PKMMAPK1 | |
| SCHEMBL22771990 | 0.72 | — | — | |
| SCHEMBL8420199 | 0.72 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1PDK1PKMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111704615-A | Imidazo [1,5-A ] pyrazine derivatives as PI3K inhibitors | 百济神州有限公司 | 2020-09-25 | — | — | CN | disclosed |
| CN-111051312-A | Imidazo [1,5-A ] pyrazine derivatives as PI3K delta inhibitors | 百济神州有限公司 | 2020-04-21 | — | — | CN | disclosed |