SCHEMBL28399044

SCHEMBL28399044

Clc1ccc(Cl)c(-c2c[nH]c(Cc3cccnc3)n2)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 1/20 0.49
ALDH1A1 P00352 2/20 0.43
HRH4 Q9H3N8 1/20 0.42
HRH3 Q9Y5N1 1/20 0.42
IDO1 P14902 2/20 0.39
CXCR2 P25025 1/20 0.39
CCNB2 O95067 1/20 0.38
CCNE2 O96020 1/20 0.38
CDK1 P06493 1/20 0.38
CDK4 P11802 1/20 0.38
CCNB1 P14635 1/20 0.38
CCND1 P24385 1/20 0.38
CCNE1 P24864 1/20 0.38
CDK2 P24941 1/20 0.38
CCNB3 Q8WWL7 1/20 0.38
NAMPT P43490 1/20 0.38
SNCA P37840 1/20 0.38
EIF2AK2 P19525 1/20 0.37
POLB P06746 1/20 0.37
ADORA2A P29274 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28398751 0.90 P2RX7 (0.44) P2RX7HRH4HRH3IDO1CXCR2
SCHEMBL26110557 0.86 CXCR2 (0.45) P2RX7ALDH1A1IDO1CXCR2
SCHEMBL28399055 0.85 RAB9A (0.40) P2RX7ALDH1A1HRH4HRH3IDO1
SCHEMBL2868906 0.83 IDO1 (0.42) ALDH1A1IDO1CXCR2MAPT
SCHEMBL28889070 0.82 P2RX7 (0.49) P2RX7ALDH1A1HRH4HRH3POLB
SCHEMBL28812735 0.82 IDO1 (0.41) P2RX7ALDH1A1IDO1CXCR2
SCHEMBL28406336 0.81 P2RX7 (0.48) P2RX7ALDH1A1HRH4HRH3IDO1
SCHEMBL28400754 0.81 HRH4 (0.44) P2RX7HRH4HRH3CCNB2CCNE2
SCHEMBL27967661 0.81 ADORA2A (0.41) ALDH1A1IDO1POLBADORA2A
SCHEMBL28406033 0.80 HRH4 (0.46) P2RX7HRH4HRH3CCNB2CCNE2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111057043-A Imidazole compound, preparation method and application thereof, organic weldable protective agent containing imidazole compound and surface treatment method 深圳市贝加电子材料有限公司 2020-04-24 CN claimed