Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.40 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.40 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28401230 | 1.00 | LMNA (0.44) | LMNAMAPTCYP2C9TSHRCHRM2 | |
| SCHEMBL28407065 | 0.82 | NPC1 (0.50) | LMNATSHRALDH1A1HPGDKMT2A | |
| SCHEMBL23891607 | 0.79 | CYP3A4 (0.46) | LMNACYP2C9CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL23891579 | 0.79 | CYP3A4 (0.46) | LMNACYP2C9CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL28401226 | 0.75 | DPP4 (0.47) | LMNAMAPTCYP2C9TSHRCHRM2 | |
| SCHEMBL28401228 | 0.75 | DPP4 (0.47) | LMNAMAPTCYP2C9TSHRCHRM2 | |
| SCHEMBL28398673 | 0.75 | CES2 (0.38) | LMNAMAPTCYP2C9TSHRCHRM2 | |
| SCHEMBL28398674 | 0.75 | CES2 (0.38) | LMNAMAPTCYP2C9TSHRCHRM2 | |
| SCHEMBL7977172 | 0.75 | CYP1A2 (0.52) | LMNACYP2C9CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL22416933 | 0.74 | CYP3A4 (0.44) | LMNAMAPTCYP2C9CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111217802-B | Histone acetylase p300 inhibitor and application thereof | 海创药业股份有限公司 | 2021-10-08 | — | — | CN | disclosed |
| CN-111217802-A | Histone acetylase p300 inhibitor and application thereof | 成都海创药业有限公司 | 2020-06-02 | — | — | CN | disclosed |