Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CPB1 | P15086 | 2/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | TLR3 | O15455 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.34 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.34 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.34 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.34 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.34 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.34 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.34 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.34 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28405305 | 1.00 | REN (0.35) | RENCYP3A4ATMCPB1PDE1C | |
| SCHEMBL20594328 | 0.87 | IRAK4 (0.34) | TLR3 | |
| SCHEMBL28407817 | 0.84 | IRAK4 (0.36) | ATMCPB1PDE1CTLR3CA1 | |
| SCHEMBL28407821 | 0.84 | IRAK4 (0.36) | ATMCPB1PDE1CTLR3CA1 | |
| SCHEMBL21852669 | 0.82 | PDE4B (0.42) | ATM | |
| SCHEMBL21852671 | 0.82 | PDE4B (0.42) | ATM | |
| SCHEMBL21852672 | 0.80 | IRAK4 (0.32) | ATMTLR3CA1CA2ACHE | |
| SCHEMBL20594485 | 0.80 | NAAA (0.33) | ATMCPB1TLR3CA1CA2 | |
| SCHEMBL21919490 | 0.71 | IRAK4 (0.38) | CPB1CA1CA2ACHECTSB | |
| SCHEMBL28404099 | 0.71 | IRAK4 (0.38) | CPB1CA1CA2ACHECTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111094292-A | Pyrazolo [1,5a ] pyrimidine derivatives as IRAK4 modulators | 豪夫迈·罗氏有限公司 | 2020-05-01 | — | — | CN | disclosed |