Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 3/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | CPB1 | P15086 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | BRD2 | P25440 | 1/20 | 0.32 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.32 |
| ▸ | TLR3 | O15455 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21852672 | 0.89 | IRAK4 (0.32) | NAAAIRAK4ATMBRD4BRD2 | |
| SCHEMBL21852671 | 0.81 | PDE4B (0.42) | PDE4BATM | |
| SCHEMBL21852669 | 0.81 | PDE4B (0.42) | PDE4BATM | |
| SCHEMBL28401644 | 0.80 | REN (0.35) | ATMCPB1TLR3CA1CA2 | |
| SCHEMBL28405305 | 0.80 | REN (0.35) | ATMCPB1TLR3CA1CA2 | |
| SCHEMBL28407817 | 0.79 | IRAK4 (0.36) | IRAK4ATMCPB1BRD4BRD2 | |
| SCHEMBL28407821 | 0.79 | IRAK4 (0.36) | IRAK4ATMCPB1BRD4BRD2 | |
| SCHEMBL20595501 | 0.76 | IRAK4 (0.32) | IRAK4ALDH1A1 | |
| SCHEMBL2535875 | 0.72 | CTSB (0.44) | NAAACPB1ALDH1A1GAA | |
| SCHEMBL20479859 | 0.69 | CPB1 (0.48) | NAAACPB1CA1CA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3642204-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | H. Hoffnabb-La Roche Ag (CH) | 2020-04-29 | — | — | EP | disclosed |
| WO-2018234345-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2018-12-27 | — | — | WO | disclosed |