Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.56 |
| ▸ | LCK | P06239 | 2/20 | 0.54 |
| ▸ | IKBKB | O14920 | 1/20 | 0.53 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 8/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.51 |
| ▸ | ALPI | P09923 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25526231 | 0.78 | MAPT (0.51) | LCKMAPTPOLBHPGDL3MBTL1 | |
| SCHEMBL30428710 | 0.77 | MEN1 (0.55) | HSD11B1IKBKBDYRK2POLBMCL1 | |
| SCHEMBL11266284 | 0.76 | ALDH1A1 (0.68) | LCKMAPTL3MBTL1MCL1ALPI | |
| SCHEMBL12127310 | 0.76 | KDM4E (0.58) | MAPTPOLBHPGDL3MBTL1PKM | |
| SCHEMBL9806400 | 0.76 | DYRK2 (0.53) | LCKDYRK2MAPTPOLBHPGD | |
| SCHEMBL14464102 | 0.76 | NPC1 (0.60) | LCKIKBKBDYRK2MAPTPOLB | |
| SCHEMBL30395714 | 0.76 | KDM4E (0.58) | MAPTPOLBHPGDL3MBTL1PKM | |
| SCHEMBL14478913 | 0.73 | SIRT2 (0.57) | MAPTPOLBHPGDL3MBTL1PKM | |
| SCHEMBL30380596 | 0.73 | SIRT2 (0.57) | MAPTPOLBHPGDL3MBTL1PKM | |
| SCHEMBL4167936 | 0.73 | HSD11B1 (0.49) | HSD11B1IKBKBDYRK2MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111233884-B | Method for synthesizing gamma-butyrolactone containing spiro 1, 3-indandione structure by using microchannel reaction device | 南京工业大学 | 2021-01-26 | — | — | CN | disclosed |
| CN-111233884-A | Method for synthesizing gamma-butyrolactone containing spiro 1, 3-indandione structure by using microchannel reaction device | 南京工业大学 | 2020-06-05 | — | — | CN | disclosed |