Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK2 | Q92630 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 10/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | PTPRC | P08575 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.46 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28561588 | 0.81 | ALDH1A1 (0.54) | DYRK2ALDH1A1HTTMAPTNPSR1 | |
| SCHEMBL30395714 | 0.76 | KDM4E (0.58) | ALDH1A1KMT2AHTTHPGDMAPT | |
| SCHEMBL11266284 | 0.76 | ALDH1A1 (0.68) | ALDH1A1KMT2AMAPTNPSR1SMN1; SMN2 | |
| SCHEMBL28401896 | 0.76 | HSD11B1 (0.56) | DYRK2ALDH1A1KMT2AHTTHPGD | |
| SCHEMBL12127310 | 0.76 | KDM4E (0.58) | ALDH1A1KMT2AHTTHPGDMAPT | |
| SCHEMBL14464102 | 0.76 | NPC1 (0.60) | DYRK2ALDH1A1KMT2AHTTHPGD | |
| SCHEMBL5481833 | 0.75 | NPC1 (0.68) | NPC1LCK | |
| SCHEMBL5481832 | 0.75 | NPC1 (0.68) | NPC1LCK | |
| SCHEMBL11268807 | 0.74 | XDH (0.62) | ALDH1A1HTTMAPTSMN1; SMN2PTPRC | |
| SCHEMBL30380596 | 0.73 | SIRT2 (0.57) | ALDH1A1KMT2AHTTHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299727-B1 | THERAPEUTIC AGENTS | Pfizer Limited (GB) | 1991-11-13 | — | — | EP | disclosed |
| US-4992447-A | Asthma | PFIZER INC. (US) | 1991-02-12 | — | — | US | disclosed |
| US-4853392-A | Fused 1,4-dihydropyridines as antiallergy and antiinflammatory agents | PFIZER INC. (US) | 1989-08-01 | — | — | US | disclosed |
| EP-0299727-A1 | Therapeutic agents | Pfizer Limited (GB) | 1989-01-18 | — | — | EP | disclosed |