Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | CDK4 | P11802 | 2/20 | 0.52 |
| ▸ | CCND1 | P24385 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9709251 | 0.92 | ABCG2 (0.68) | ABCG2KDM4ECDK4CCND1ALDH1A1 | |
| SCHEMBL14543827 | 0.84 | PARP1 (0.62) | KDM4ECDK4CCND1ALDH1A1SMN1; SMN2 | |
| SCHEMBL28104195 | 0.82 | ABCG2 (0.82) | ABCG2KDM4ECDK4CCND1ALDH1A1 | |
| SCHEMBL27174159 | 0.82 | MAPT (0.65) | KDM4EALDH1A1MAPTHPGDLMNA | |
| SCHEMBL12015108 | 0.81 | PARP1 (0.58) | KDM4ECDK4CCND1ALDH1A1SMN1; SMN2 | |
| SCHEMBL29586144 | 0.81 | PARP1 (0.58) | KDM4ECDK4CCND1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2330779 | 0.78 | KDM4E (0.68) | ABCG2KDM4ECDK4CCND1ALDH1A1 | |
| SCHEMBL29533596 | 0.78 | KDM4E (0.68) | ABCG2KDM4ECDK4CCND1ALDH1A1 | |
| SCHEMBL13438413 | 0.78 | ACHE (0.53) | KDM4EALDH1A1MAPTPARP1CTSV | |
| SCHEMBL14543826 | 0.78 | PARP1 (0.59) | KDM4EALDH1A1MAPTSMN1; SMN2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105884686-B | 10-substituted acridine-3 (10) -ketone compound, preparation method and application thereof | 中国药科大学 | 2020-06-09 | — | — | CN | disclosed |