Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 4/20 | 0.36 |
| ▸ | CA1 | P00915 | 4/20 | 0.36 |
| ▸ | CA9 | Q16790 | 4/20 | 0.36 |
| ▸ | PREP | P48147 | 4/20 | 0.36 |
| ▸ | ELANE | P08246 | 3/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2995063 | 0.76 | HTT (0.49) | MEN1KMT2AELANE | |
| SCHEMBL4339762 | 0.75 | TSHR (0.47) | KMT2ACA12CA1CA9 | |
| SCHEMBL2993051 | 0.75 | DRD2 (0.34) | CA12CA1CA9DRD2 | |
| SCHEMBL2995878 | 0.74 | MAPT (0.45) | MEN1KMT2A | |
| SCHEMBL4330970 | 0.73 | ALDH1A1 (0.48) | MEN1KMT2ACA12CA1CA9 | |
| SCHEMBL11903657 | 0.73 | CA12 (0.38) | MEN1KMT2ACA12CA1CA9 | |
| SCHEMBL14992971 | 0.72 | HTR2A (0.36) | MEN1KMT2ACA12CA1CA9 | |
| SCHEMBL3963273 | 0.72 | MAPT (0.42) | MEN1KMT2ACA12CA1CA9 | |
| SCHEMBL17603155 | 0.72 | GRM4 (0.43) | — | |
| SCHEMBL23753577 | 0.71 | MEN1 (0.57) | MEN1KMT2ACA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117695280-A | Pyridin-2 (1H) -one quinolinone derivatives as mutant isocitrate dehydrogenase inhibitors | 福马治疗股份有限公司 | 2024-03-15 | — | — | CN | disclosed |
| CN-111909130-B | Pyridin-2 (1H) -one quinolinone derivatives as mutant isocitrate dehydrogenase inhibitors | 福马治疗股份有限公司 | 2023-10-31 | — | — | CN | disclosed |
| CN-111909130-A | Pyridin-2 (1H) -one quinolinone derivatives as mutant isocitrate dehydrogenase inhibitors | 福马治疗股份有限公司 | 2020-11-10 | — | — | CN | disclosed |
| CN-107001328-B | Pyridin-2 (1H) -one quinolinone derivatives as mutant isocitrate dehydrogenase inhibitors | 福马治疗股份有限公司 | 2020-06-05 | — | — | CN | disclosed |