Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MYC | P01106 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29099930 | 0.81 | L3MBTL1 (0.43) | L3MBTL1ALDH1A1GAAHTTSMN1; SMN2 | |
| SCHEMBL22557510 | 0.80 | MYC (0.50) | KDM4EALDH1A1MYCGLAGAA | |
| SCHEMBL31272334 | 0.74 | GRM4 (0.36) | L3MBTL1KDM4EALDH1A1MYCMAPT | |
| SCHEMBL30232753 | 0.72 | L3MBTL1 (0.60) | L3MBTL1KDM4EALDH1A1TP53GLA | |
| SCHEMBL126054 | 0.72 | L3MBTL1 (0.60) | L3MBTL1KDM4EALDH1A1TP53GLA | |
| SCHEMBL15714563 | 0.72 | MYC (0.69) | L3MBTL1KDM4EALDH1A1MYCTP53 | |
| SCHEMBL28402470 | 0.71 | ALDH1A1 (0.40) | KDM4EALDH1A1GLAGAACYP1A2 | |
| SCHEMBL29276692 | 0.70 | MAPK1 (0.49) | L3MBTL1KDM4EALDH1A1GLAGAA | |
| SCHEMBL22580254 | 0.69 | TP53 (0.58) | L3MBTL1ALDH1A1TP53GAACYP1A2 | |
| SCHEMBL394073 | 0.69 | L3MBTL1 (0.60) | L3MBTL1KDM4EALDH1A1PARP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111196804-B | TGF-beta R1 inhibitors and uses thereof | 南京圣和药业股份有限公司 | 2023-11-07 | — | — | CN | disclosed |
| CN-111196804-A | TGF- β R1 inhibitor and application thereof | 南京圣和药业股份有限公司 | 2020-05-26 | — | — | CN | disclosed |