SCHEMBL394073

SCHEMBL394073

COC(=O)c1ncccc1Br

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.60
ALOX15 P16050 2/20 0.45
MAP2K1 Q02750 1/20 0.45
HTT P42858 1/20 0.45
ALDH1A1 P00352 3/20 0.44
KDM4E B2RXH2 5/20 0.44
TDP1 Q9NUW8 1/20 0.44
TSHR P16473 2/20 0.43
POLB P06746 1/20 0.43
GAA P10253 1/20 0.43
NPSR1 Q6W5P4 2/20 0.43
BRD4 O60885 1/20 0.42
TLR7 Q9NYK1 1/20 0.41
MAPT P10636 2/20 0.40
F2 P00734 1/20 0.40
KMT2A Q03164 1/20 0.40
PARP1 P09874 1/20 0.40
PKM P14618 1/20 0.40
CYP3A4 P08684 1/20 0.40
BLM P54132 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL108876 0.83 L3MBTL1 (0.62) L3MBTL1ALOX15MAP2K1HTTALDH1A1
Hydrochloric Acid SCHEMBL6569637 0.81 L3MBTL1 (0.60) L3MBTL1ALOX15MAP2K1HTTALDH1A1
SCHEMBL28177117 0.81 KDM4E (0.40) L3MBTL1ALOX15HTTALDH1A1KDM4E
SCHEMBL69177 0.81 L3MBTL1 (0.64) L3MBTL1ALOX15MAP2K1HTTALDH1A1
SCHEMBL21358025 0.81 GABRA1 (0.42) L3MBTL1ALOX15HTTALDH1A1KDM4E
SCHEMBL6759202 0.81 BRD4 (0.60) L3MBTL1HTTALDH1A1KDM4ETSHR
SCHEMBL3653582 0.80 L3MBTL1 (0.58) L3MBTL1ALOX15MAP2K1HTTALDH1A1
SCHEMBL29416324 0.79 L3MBTL1 (0.62) L3MBTL1ALOX15MAP2K1HTTALDH1A1
SCHEMBL31347575 0.79 L3MBTL1 (0.62) L3MBTL1ALOX15MAP2K1HTTALDH1A1
SCHEMBL69990 0.79 L3MBTL1 (0.62) L3MBTL1ALOX15MAP2K1HTTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 280 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116348115-B Combination of antibody-drug conjugate and PARP1 selective inhibitor ASTRAZENECA UK LTD. (GB) 2026-05-26 CN disclosed
US-20260138956-A1 NOVEL COMPOUNDS AND USES THEREOF RECURSION PHARMACEUTICALS INC (US) 2026-05-21 US disclosed
EP-4743457-A1 INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 FOR THERAPEUTIC USE 4M THERAPEUTICS INC. (US) 2026-05-20 EP disclosed
CN-122059929-A Quinoxaline derivatives as anticancer agents 阿斯利康(瑞典)有限公司 2026-05-19 CN disclosed
CN-122036687-A Quinoxaline derivatives as anticancer agents 阿斯利康(瑞典)有限公司 2026-05-15 CN disclosed
CN-122036686-A Quinoxaline derivatives as anticancer agents 阿斯利康(瑞典)有限公司 2026-05-15 CN disclosed
CN-122010903-A Quinoxaline derivatives as anticancer agents 阿斯利康(瑞典)有限公司 2026-05-12 CN disclosed
US-12616682-B2 1-H-pyrrolo[2,3-c]pyridine compounds ACERTA PHARMA B.V. (NL) 2026-05-05 US disclosed
US-20260103454-A1 MODULATORS OF HEMOGLOBIN GLOBAL BLOOD THERAPEUTICS INC (US) 2026-04-16 US disclosed
EP-4688776-A1 1-H-PYRROLO[2,3-C]PYRIDINE COMPOUNDS ACTING AGAINST CANCER VIA AGONISM OF MENIN Acerta Pharma B.V. (NL) 2026-02-11 EP disclosed
US-6693210-B2 USING PALLADIUM, NICKEL PHOSPHINE COMPLEX AS CATALYSTS MITSUBISHI RAYON CO., LTD. (JP) 2004-02-17 US disclosed
US-20040006226-A1 Isoxazole pyrazoloindane derivatives as cognition enhancing GABA-A alpha 5 subtype ligands MERCK SHARP & DOHME LTD. (GB) 2004-01-08 US disclosed
WO-2003037904-A1 NOVEL 3BETA-AMINO AZABICYCLOOCTANE HETEROAROMATIC AMIDE DERIVATIVES, PREPARATION METHOD AND THERAPEUTIC USES THEREOF PIERRE FABRE MEDICAMENT (FR) 2003-05-08 WO disclosed
US-20030065208-A1 Using palladium, nickel phosphine complex as catalysts MITSUBISHI RAYON CO., LTD. (JP) 2003-04-03 US disclosed
EP-1270582-A1 TRIPHENYLPHOSPHINE DERIVATIVE, PRODUCTION PROCESS THEREFOR, PALLADIUM COMPLEX THEREOF, AND PROCESS FOR PRODUCING BIARYL DERIVATIVE Mitsubishi Rayon Co., Ltd. (JP) 2003-01-02 EP disclosed
EP-0801648-A4 SUBSTITUTED 2-ARYLCARBONYLOXYMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF SANOFI WINTHROP INC (US) 1998-01-28 EP disclosed
EP-0801648-A1 SUBSTITUTED 2-ARYLCARBONYLOXYMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF SANOFI WINTHROP, INC. (US) 1997-10-22 EP disclosed
US-5556909-A PROTEOLYTIC ENZYME INHIBITOR, TREATMENT OF DEGENERATIVE DISEASES, SUCH AS EMPHYSEMA, RHEUMATOID ARTHRITIS AND PANCREATITIS SANOFI WINTHROP INC. (US) 1996-09-17 US disclosed
WO-1996016951-A1 SUBSTITUTED 2-ARYLCARBONYLOXYMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF SANOFI WINTHROP, INC. (US) 1996-06-06 WO disclosed
US-3963733-A 3-(P-methoxybenzylthio)2-non-oxocarbonylic pyridines SMITHKLINE CORPORATION (US) 1976-06-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260138956-A1 NOVEL COMPOUNDS AND USES THEREOF SLC10A1, NR3C2, CYP2C8 L3MBTL1 3399/4885ALOX15 1263/4885MAP2K1 3995/4885
US-20030065208-A1 Using palladium, nickel phosphine complex as catalysts PDCD1LG2, PIK3CA, PDCD1 L3MBTL1 3393/4885ALOX15 1440/4885MAP2K1 867/4885
US-20260103454-A1 MODULATORS OF HEMOGLOBIN HBZ, HBB, HBG2 L3MBTL1 4612/4885ALOX15 2454/4885MAP2K1 1109/4885
US-20040006226-A1 Isoxazole pyrazoloindane derivatives as cognition enhancing GABA-A alpha 5 subtype ligands GABRA5, GABRB1, GABRA4 L3MBTL1 4478/4885ALOX15 1670/4885MAP2K1 4635/4885
US-12616682-B2 1-H-pyrrolo[2,3-c]pyridine compounds MEN1, PKD1, PKD2 L3MBTL1 4825/4885ALOX15 4816/4885MAP2K1 1061/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.