Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10354328 | 0.88 | MEN1 (0.44) | KMT2AMEN1MAPK1TSHRTHRB | |
| SCHEMBL7573626 | 0.85 | TSHR (0.38) | KMT2AMEN1MAPK1TSHRTHRB | |
| Tetraethylene Glycol SCHEMBL9189750 | 0.81 | MEN1 (0.37) | KMT2AMEN1MAPK1TSHRTHRB | |
| Fumaric Acid SCHEMBL9719235 | 0.80 | HSD17B10 (0.44) | KMT2AMEN1HCAR2MAPK1TSHR | |
| Maleic Acid SCHEMBL9719226 | 0.80 | HSD17B10 (0.44) | KMT2AMEN1HCAR2MAPK1TSHR | |
| Fumaric Acid SCHEMBL9719239 | 0.80 | HSD17B10 (0.44) | KMT2AMEN1HCAR2MAPK1TSHR | |
| Fumaric Acid SCHEMBL9719243 | 0.80 | HSD17B10 (0.44) | KMT2AMEN1HCAR2MAPK1TSHR | |
| Triethylene Glycol SCHEMBL29634750 | 0.77 | MEN1 (0.58) | KMT2AMEN1HCAR2MAPK1TSHR | |
| Triethylene Glycol SCHEMBL22117113 | 0.77 | MEN1 (0.58) | KMT2AMEN1HCAR2MAPK1TSHR | |
| Triethylene Glycol SCHEMBL15282147 | 0.77 | MEN1 (0.58) | KMT2AMEN1HCAR2MAPK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107758687-B | Synthesis method of disk-shaped mordenite with different thicknesses | 中国石油化工股份有限公司 | 2020-06-09 | — | — | CN | disclosed |