Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 known ✓ | O00255 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL9719226 | 1.00 | HSD17B10 (0.44) | HSD17B10KMT2AMEN1HCAR2TSHR | |
| Fumaric Acid SCHEMBL9719239 | 1.00 | HSD17B10 (0.44) | HSD17B10KMT2AMEN1HCAR2TSHR | |
| Fumaric Acid SCHEMBL9719235 | 1.00 | HSD17B10 (0.44) | HSD17B10KMT2AMEN1HCAR2TSHR | |
| Tetraethylene Glycol SCHEMBL28463864 | 0.89 | MEN1 (0.42) | KMT2AMEN1HCAR2TSHRMAPK1 | |
| Acrylic Acid SCHEMBL6667897 | 0.88 | HSD17B10 (0.42) | HSD17B10KMT2AMEN1TSHRMAPK1 | |
| Hexaethylene Glycol SCHEMBL9719257 | 0.87 | HSD17B10 (0.34) | HSD17B10TDP1 | |
| Fumaric Acid SCHEMBL9719211 | 0.87 | HSD17B10 (0.34) | HSD17B10TDP1 | |
| Fumaric Acid SCHEMBL9719203 | 0.87 | HSD17B10 (0.34) | HSD17B10TDP1 | |
| SCHEMBL4381920 | 0.85 | HSD17B10 (0.47) | HSD17B10KMT2AMEN1TSHRMAPK1 | |
| Styrene SCHEMBL9719288 | 0.85 | ALDH1A1 (0.39) | KMT2AMEN1HCAR2TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162402-A | For concrete containing a polymeric composition | SANDOZ LTD. (CH) | 1992-11-10 | — | — | US | disclosed |