Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | AHR | P35869 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.44 |
| ▸ | CIT | O14578 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.44 |
| ▸ | STK17B | O94768 | 1/20 | 0.44 |
| ▸ | STK10 | O94804 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28182145 | 0.88 | EGFR (0.51) | EGFRKDREPHB4ERBB2RET | |
| SCHEMBL28181381 | 0.82 | EGFR (0.53) | EGFRMAPTKDREPHB4GAK | |
| SCHEMBL28407489 | 0.81 | EGFR (0.76) | EGFRMAPTSRCKDREPHB4 | |
| SCHEMBL28700309 | 0.78 | EGFR (0.91) | EGFRMAPTSRCKDREPHB4 | |
| SCHEMBL28709898 | 0.77 | EGFR (1.00) | EGFRMAPTSRCKDREPHB4 | |
| SCHEMBL28181387 | 0.76 | EGFR (0.63) | EGFRMAPTSRCKDREPHB4 | |
| SCHEMBL7475167 | 0.74 | EGFR (0.51) | EGFRMAPTMAPK1AHRHTT | |
| SCHEMBL28409241 | 0.73 | EPHA2 (0.49) | EGFRKDREPHB4EPHA2 | |
| SCHEMBL28180909 | 0.72 | MAPT (0.50) | EGFRMAPTMAPK1HTTNPC1 | |
| SCHEMBL28407547 | 0.70 | EGFR (0.49) | EGFRRETABCG2EPHA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107200715-B | Quinazoline derivative and application thereof in preparation of antitumor drugs | 陕西师范大学 | 2020-05-29 | — | — | CN | disclosed |
| CN-107200715-A | Quinazoline derivant and its application in antineoplastic is prepared | 陕西师范大学 | 2017-09-26 | — | — | CN | disclosed |