Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HHAT | Q5VTY9 | 2/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | LHCGR | P22888 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2838307 | 0.88 | KDM4E (0.38) | KDM4ECCR2KCNH2SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL2837155 | 0.87 | KDM4E (0.37) | OPRD1KDM4EKCNH2SLC6A2SLC6A4 | |
| SCHEMBL2836992 | 0.85 | KDM4E (0.38) | OPRD1KDM4EHHATKCNH2SLC6A2 | |
| Hydrochloric Acid SCHEMBL2840931 | 0.84 | OPRD1 (0.38) | OPRD1KDM4EHHATKCNH2SLC6A2 | |
| SCHEMBL2841690 | 0.83 | OPRD1 (0.40) | OPRD1KDM4ESLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2843946 | 0.77 | NPC1 (0.42) | KDM4EKCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2840993 | 0.75 | OPRD1 (0.36) | OPRD1KCNH2 | |
| SCHEMBL2840576 | 0.75 | DRD3 (0.36) | HHATKCNH2SLC6A4SIGMAR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2841695 | 0.74 | SLC6A4 (0.34) | KDM4EKCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2834956 | 0.74 | HHAT (0.38) | KDM4EHHATALDH1A1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217031-B2 | Heteroaryl derivatives | NIPPON SHINYAKU CO., LTD. (JP) | 2012-07-10 | — | — | US | disclosed |
| US-20100048537-A1 | HETEROARYL DERIVATIVES | NIPPON SHINYAKU CO., LTD. (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2141168-A1 | HETEROARYL DERIVATIVES | Nippon Shinyaku Co., Ltd. (JP) | 2010-01-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048537-A1 | HETEROARYL DERIVATIVES | OPRD1, OPRM1, OPRK1 | OPRD1 1/4885KDM4E 3292/4885HHAT 986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.