Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 9/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 9/20 | 0.36 |
| ▸ | FDPS | P14324 | 3/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.32 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.32 |
| ▸ | SMPD1 | P17405 | 5/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL11590421 | 0.82 | MEN1 (0.40) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| Tromethamine SCHEMBL57832 | 0.81 | MEN1 (0.36) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| Tromethamine SCHEMBL1714393 | 0.81 | MEN1 (0.36) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| Ethylene Glycol SCHEMBL9064983 | 0.81 | SMPD1 (0.36) | SMPD1 | |
| SCHEMBL4940649 | 0.81 | — | — | |
| SCHEMBL27590178 | 0.79 | — | — | |
| SCHEMBL27658320 | 0.79 | — | — | |
| Tromethamine SCHEMBL1843995 | 0.78 | S1PR1 (0.40) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| Tromethamine SCHEMBL20548564 | 0.77 | MEN1 (0.39) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| Tromethamine SCHEMBL8860394 | 0.77 | SMPD1 (0.43) | MEN1LMNAKMT2AS1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 622 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119447295-A | Positive electrode plate, battery and electricity utilization device | 宁德时代新能源科技股份有限公司 | 2025-02-14 | — | — | CN | claimed |
| CN-119301213-A | Two-component thermally conductive compositions of silane-based polymers | 波士胶公司 | 2025-01-10 | — | — | CN | claimed |
| CN-118645715-A | Method for improving cycle performance of lithium metal battery and application thereof | 上海轩邑新能源发展有限公司 | 2024-09-13 | — | — | CN | claimed |
| CN-115975163-A | Modified polyester resin, preparation method thereof and heat-insulating halogen-free flame-retardant powder coating | 安徽神剑新材料股份有限公司 | 2023-04-18 | — | — | CN | claimed |
| CN-113773463-B | Polyether composition, polyurethane rigid foam using polyether composition as raw material and preparation method of polyurethane rigid foam | 佳化化学科技发展（上海）有限公司 | 2023-01-06 | — | — | CN | claimed |
| CN-114907713-A | Aluminum-magnesium composite flame retardant and preparation method thereof | 合肥中科阻燃新材料有限公司 | 2022-08-16 | — | — | CN | claimed |
| CN-111848961-B | Preparation method of modified polyamide extreme pressure lubricant for high-efficiency drilling fluid | 荆州市学成实业有限公司 | 2022-04-08 | — | — | CN | claimed |
| CN-113773463-A | Polyether composition, polyurethane rigid foam using polyether composition as raw material and preparation method of polyurethane rigid foam | 佳化化学科技发展（上海）有限公司 | 2021-12-10 | — | — | CN | claimed |
| CN-110176630-B | Electrolyte solution and electrochemical device using the same | 宁德新能源科技有限公司 | 2021-06-25 | — | — | CN | claimed |
| CN-112979860-A | Wear-resistant flame-retardant organic glass plate and preparation method thereof | 安徽新涛光电科技有限公司 | 2021-06-18 | — | — | CN | claimed |
| CN-112538226-A | Flame-retardant PMMA light diffusion plate and preparation method thereof | 安徽新涛光电科技有限公司 | 2021-03-23 | — | — | CN | claimed |
| CN-109560323-B | Gel polymer electrolyte and electrochemical device comprising same | 宁德新能源科技有限公司 | 2021-01-19 | — | — | CN | claimed |
| CN-111848961-A | Preparation method of modified polyamide extreme pressure lubricant for high-efficiency drilling fluid | 荆州市学成实业有限公司 | 2020-10-30 | — | — | CN | claimed |
| US-6537472-B2 | Process for producing a cushioning article | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2003-03-25 | — | — | US | claimed |
| EP-0352729-B1 | Sheet for forming article having electromagnetic wave shieldability | TOYO ALUMINIUM KK (JP) | 1994-07-13 | — | — | EP | claimed |
| US-4980223-A | HOUSING FOR ELECTRONIC EQUIPMENT | TOYO ALUMINIUM KABUSHIKI KAISHA (JP) | 1990-12-25 | — | — | US | claimed |
| EP-0352729-A2 | Sheet for forming article having electromagnetic wave shieldability | TOYO ALUMINIUM KABUSHIKI KAISHA (JP) | 1990-01-31 | — | — | EP | claimed |
| US-3936562-A | Fire retardant fabrics | UNITED MERCHANTS AND MANUFACTURERS, INC. (US) | 1976-02-03 | — | — | US | claimed |
| CN-116659004-B | Air conditioner | DAIKIN INDUSTRIES, LTD. (JP) | 2026-05-26 | — | — | CN | disclosed |
| US-3931065-A | POLYURETHANE-MODIFIED POLYISOCYANURATE FOAM AND A METHOD FOR THE PREPARATION THEREOF | NISSHIN BOSEKI KABUSHIKI KAISHA (JA) | 1976-01-06 | — | — | US | disclosed |