Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 8/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 8/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.31 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.31 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1666010 | 0.84 | — | — | |
| SCHEMBL10803952 | 0.82 | MAPK1 (0.42) | MAPK1SMPD1 | |
| SCHEMBL27931739 | 0.82 | MAPK1 (0.42) | MAPK1SMPD1 | |
| Tromethamine SCHEMBL20548564 | 0.81 | MEN1 (0.39) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| Tromethamine SCHEMBL284082 | 0.81 | MEN1 (0.39) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| Tromethamine SCHEMBL11590421 | 0.79 | MEN1 (0.40) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| Triaziquone SCHEMBL21609578 | 0.76 | — | — | |
| Tromethamine SCHEMBL1714393 | 0.75 | MEN1 (0.36) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| Tromethamine SCHEMBL8860394 | 0.74 | SMPD1 (0.43) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| SCHEMBL28668769 | 0.72 | MAPK1 (0.43) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 479 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116601198-B | Polyurethane composite material, laminate product comprising the same and method for preparing the same | 巴斯夫欧洲公司 | 2024-12-27 | — | — | CN | claimed |
| CN-118771355-A | Biomass hard carbon negative electrode material, preparation method thereof and sodium ion battery | 四川佰思格新能源有限公司 | 2024-10-15 | — | — | CN | claimed |
| CN-118754095-A | Resin-based hard carbon negative electrode material, preparation method thereof and sodium ion battery | 四川佰思格新材料科技有限公司 | 2024-10-11 | — | — | CN | claimed |
| CN-118638289-A | Foam plastic capable of reducing vibration and noise and preparation method thereof | 湖南省森研高分子新材料股份有限公司 | 2024-09-13 | — | — | CN | claimed |
| CN-118624796-A | Synchronous extraction pretreatment method and detection method for multiple types of semi-volatile organic compounds in food | 广东工业大学 | 2024-09-10 | — | — | CN | claimed |
| CN-118414389-A | Expandable coating composition cured by application of pulsed infrared radiation | PPG涂料欧洲有限责任公司 | 2024-07-30 | — | — | CN | claimed |
| CN-118258921-A | Method for detecting low-clustering and halogenated organic phosphate compounds in breast milk | 上海大学 | 2024-06-28 | — | — | CN | claimed |
| CN-113121780-B | Composition comprising a novolac | 巴克莱特有限公司 | 2024-05-17 | — | — | CN | claimed |
| CN-113631611-B | Polyurethane/polyisocyanurate foam blocks of the insulating body of a tank and method for the production thereof | 气体运输技术公司 | 2024-02-23 | — | — | CN | claimed |
| US-11898304-B2 | Antimony free brominated flame retardant system for textiles | BROMINE COMPOUNDS LTD. (IL) | 2024-02-13 | — | — | US | claimed |
| EP-2841282-B1 | FABRIC PRINT MEDIA | HEWLETT PACKARD DEVELOPMENT CO LP (US) | 2017-11-01 | — | — | EP | claimed |
| EP-2855162-B1 | FABRIC PRINT MEDIA | HEWLETT PACKARD DEVELOPMENT CO (US) | 2016-11-16 | — | — | EP | claimed |
| EP-2855162-A2 | FABRIC PRINT MEDIA | Hewlett-Packard Development Company, L.P. (US) | 2015-04-08 | — | — | EP | claimed |
| EP-2841282-A1 | FABRIC PRINT MEDIA | Hewlett-Packard Development Company, L.P. (US) | 2015-03-04 | — | — | EP | claimed |
| WO-2014168600-A2 | FABRIC PRINT MEDIA | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) | 2014-10-16 | — | — | WO | claimed |
| US-20140234557-A1 | Artificial Carvable Items and Methods of Manufacture | FUN-KINS LIMITED (US) | 2014-08-21 | — | — | US | claimed |
| WO-2013162578-A1 | FABRIC PRINT MEDIA | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) | 2013-10-31 | — | — | WO | claimed |
| US-20040116545-A1 | Two-component foam system for producing constructional foams and their use | HILTI AKTIENGESELLSCHAFT (LI) | 2004-06-17 | — | — | US | claimed |
| WO-2003016386-A1 | AN ACOUSTICALLY ABSORBANT FOAM WITH ELASTIC PROPERTIES | BEATTY SIMON PAKENHAM MCNEALE (GB) | 2003-02-27 | — | — | WO | claimed |
| CN-1183790-A | Method of producing rigid foams and products produced therefrom | EXXON CHEMICAL PATENTS INC (US) | 1998-06-03 | — | — | CN | claimed |