Ammonia Solution, Strong

Ammonia Solution, Strong

SCHEMBL28408262

Cc1ccncc1OCC(F)(F)F.N

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP17A1 P05093 6/20 0.50
SSTR4 P31391 3/20 0.44
CHRNB2 P17787 1/20 0.43
CHRNA4 P43681 1/20 0.43
CYP1A2 P05177 2/20 0.38
GSK3B P49841 4/20 0.38
MAPT P10636 2/20 0.38
PDE2A O00408 1/20 0.38
PDE10A Q9Y233 1/20 0.38
ALDH1A1 P00352 2/20 0.38
KDM4E B2RXH2 1/20 0.38
MEN1 O00255 1/20 0.38
USP2 O75604 1/20 0.38
HSP90AA1 P07900 1/20 0.38
HSP90AB1 P08238 1/20 0.38
THRB P10828 1/20 0.38
G6PD P11413 1/20 0.38
ALOX15 P16050 1/20 0.38
CASP1 P29466 1/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28160859 0.98 CYP17A1 (0.51) CYP17A1SSTR4CHRNB2CHRNA4CYP1A2
Ethoxycarbonyl Group SCHEMBL28080942 0.84 CYP17A1 (0.45) CYP17A1SSTR4CHRNB2CHRNA4CYP1A2
SCHEMBL4397933 0.84 CYP17A1 (0.51) CYP17A1SSTR4CYP1A2GSK3BMAPT
Ammonia Solution, Strong SCHEMBL28411555 0.83 CHRNB2 (0.42) CYP17A1SSTR4CHRNB2CHRNA4CYP1A2
SCHEMBL28080949 0.82 SSTR4 (0.42) CYP17A1SSTR4CHRNB2CHRNA4CYP1A2
SCHEMBL16252776 0.79 SSTR4 (0.47) CYP17A1SSTR4CHRNB2CHRNA4CYP1A2
Formic Acid SCHEMBL28012981 0.79 SSTR4 (0.47) CYP17A1SSTR4CHRNB2CHRNA4GSK3B
SCHEMBL17610600 0.77 CYP17A1 (0.40) CYP17A1SSTR4GSK3BMAPTALDH1A1
SCHEMBL28151932 0.77 CYP17A1 (0.45) CYP17A1SSTR4GSK3BMAPTALDH1A1
Ammonia Solution, Strong SCHEMBL28411378 0.76 CYP17A1 (0.50) CYP17A1SSTR4CHRNB2CHRNA4CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107406417-B 4H-pyrrolo [3,2-c ] pyridin-4-one derivatives 拜耳制药股份公司 2020-06-09 CN disclosed