SCHEMBL28409771

SCHEMBL28409771

CC(C)CNC(=O)NCC#CC#CCNC(=O)NCC(C)C

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 2/20 0.48
CYP2C19 P33261 2/20 0.48
CYP2D6 P10635 1/20 0.48
MAPT P10636 3/20 0.44
MMP1 P03956 1/20 0.42
MMP8 P22894 1/20 0.42
HSD17B10 Q99714 2/20 0.41
KDM4E B2RXH2 2/20 0.41
TP53 P04637 1/20 0.41
LMNA P02545 2/20 0.39
CYP2C9 P11712 1/20 0.37
FAAH O00519 1/20 0.36
CNR2 P34972 1/20 0.36
KMT2A Q03164 2/20 0.36
GAA P10253 1/20 0.36
TAS1R3 Q7RTX0 1/20 0.35
TAS1R1 Q7RTX1 1/20 0.35
TAS1R2 Q8TE23 1/20 0.35
ALDH1A1 P00352 3/20 0.34
MEN1 O00255 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1275889 0.83 CYP2D6 (0.65) EPHX1CYP2C19CYP2D6MAPTMMP1
SCHEMBL28409872 0.79 ANPEP (0.44) EPHX1CYP2C19MMP8HSD17B10LMNA
SCHEMBL28407679 0.76 EPHX1 (0.43) EPHX1KMT2AGAAMEN1
SCHEMBL28407858 0.75 EPHX1 (0.46) EPHX1KDM4E
SCHEMBL965868 0.75 EPHX1 (0.59) EPHX1CYP2C19CYP2D6MAPTMMP1
SCHEMBL11020159 0.75 MCL1 (0.38) EPHX1MMP1MMP8FAAHKMT2A
SCHEMBL16674188 0.74 CYP2D6 (0.48) EPHX1CYP2C19CYP2D6MAPTMMP1
SCHEMBL28403927 0.74 EPHX1 (0.49) EPHX1KDM4E
SCHEMBL16801793 0.73 CYP2D6 (0.52) EPHX1CYP2C19CYP2D6MAPTMMP1
SCHEMBL15148253 0.73 CYP2D6 (0.52) EPHX1CYP2C19CYP2D6MAPTMMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111269128-B Synthesis method of 1,1' - (hexa-2, 4-diyne-1, 6-diyl) bis (3-alkyl urea) compound 苏州爱玛特生物科技有限公司 2022-08-30 CN disclosed
CN-111269128-A Synthesis method of 1, 1' - (hexa-2, 4-diyne-1, 6-diyl) bis (3-alkyl urea) compound 苏州爱玛特生物科技有限公司 2020-06-12 CN disclosed