Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 6/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | DHFR | P00374 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | EDNRA | P25101 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | HTR6 | P50406 | 4/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL152522 | 0.98 | SMN1; SMN2 (0.65) | SMN1; SMN2LMNAAURKADHFRTSHR | |
| SCHEMBL19332648 | 0.83 | KDM4E (0.47) | SMN1; SMN2LMNAAURKADHFRTSHR | |
| SCHEMBL15880397 | 0.83 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAKDM4EALDH1A1EDNRA | |
| SCHEMBL1094138 | 0.82 | POLB (0.55) | SMN1; SMN2LMNAKDM4EALDH1A1KMT2A | |
| Sulfapyridine SCHEMBL668918 | 0.79 | SMN1; SMN2 (0.97) | SMN1; SMN2LMNAAURKADHFRTSHR | |
| SCHEMBL19332434 | 0.79 | CA1 (0.49) | SMN1; SMN2TSHRKDM4EALDH1A1KMT2A | |
| Sulfapyridine SCHEMBL668917 | 0.78 | SMN1; SMN2 (0.94) | SMN1; SMN2LMNAAURKADHFRTSHR | |
| Sulfapyridine SCHEMBL44219 | 0.78 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAAURKADHFRTSHR | |
| Sulfapyridine SCHEMBL29438089 | 0.78 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAAURKADHFRTSHR | |
| SCHEMBL6292016 | 0.78 | SLC40A1 (0.55) | SMN1; SMN2KMT2AMEN1EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111303055-B | Quinazoline derivative and preparation method and application thereof | 中国农业科学院兰州畜牧与兽药研究所 | 2021-12-24 | — | — | CN | disclosed |
| CN-111303055-A | Quinazoline derivative and preparation method and application thereof | 中国农业科学院兰州畜牧与兽药研究所 | 2020-06-19 | — | — | CN | disclosed |