Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 5/20 | 0.55 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | EDNRA | P25101 | 1/20 | 0.49 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CKS1B | P61024 | 3/20 | 0.48 |
| ▸ | SKP2 | Q13309 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | SNCA | P37840 | 1/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1094138 | 0.88 | POLB (0.55) | KEAP1KMT2AEDNRAGAAMEN1 | |
| SCHEMBL19332648 | 0.80 | KDM4E (0.47) | EDNRASMN1; SMN2 | |
| SCHEMBL152522 | 0.79 | SMN1; SMN2 (0.65) | KMT2AEDNRAMEN1SMN1; SMN2 | |
| SCHEMBL15880397 | 0.79 | SMN1; SMN2 (0.56) | EDNRASMN1; SMN2 | |
| SCHEMBL25382203 | 0.78 | SMN1; SMN2 (0.52) | SLC40A1GLO1KEAP1NFE2L2KMT2A | |
| SCHEMBL3477271 | 0.78 | SLC40A1 (0.50) | SLC40A1GLO1KEAP1NFE2L2KMT2A | |
| SCHEMBL30354832 | 0.78 | SMN1; SMN2 (0.52) | SLC40A1GLO1KEAP1NFE2L2KMT2A | |
| SCHEMBL28409808 | 0.78 | SMN1; SMN2 (0.63) | KMT2AEDNRAMEN1SMN1; SMN2 | |
| SCHEMBL6811801 | 0.77 | SLC40A1 (0.56) | SLC40A1GLO1KEAP1NFE2L2KMT2A | |
| SCHEMBL9302174 | 0.76 | MAPT (0.68) | KMT2AEDNRACA2GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6943254-B2 | Synthesis of pyrazinyl pyridine-3-sulfonamide compounds | ASTRAZENECA UK LIMITED (GB) | 2005-09-13 | — | — | US | disclosed |