Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 3/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29565779 | 1.00 | MAPT (0.44) | MAPTNPC1KDM4EGAAHSD17B10 | |
| Hydrochloric Acid SCHEMBL28411373 | 0.99 | MAPT (0.43) | MAPTNPC1KDM4EGAAHSD17B10 | |
| Hydrochloric Acid SCHEMBL29565430 | 0.99 | MAPT (0.43) | MAPTNPC1KDM4EGAAHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL29566185 | 0.88 | MAPT (0.37) | MAPTNPC1KDM4EGAAHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL28416274 | 0.88 | MAPT (0.37) | MAPTNPC1KDM4EGAAHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL29566493 | 0.88 | MAPT (0.37) | MAPTNPC1KDM4EGAAHSD17B10 | |
| SCHEMBL28300570 | 0.71 | CYP1A1 (0.52) | NPC1KDM4EGAAHSD17B10L3MBTL1 | |
| SCHEMBL14596555 | 0.70 | DHFR (0.54) | MAPTNPC1KDM4EHSD17B10RAB9A | |
| SCHEMBL18027880 | 0.68 | L3MBTL1 (0.59) | MAPTNPC1KDM4EGAAHSD17B10 | |
| SCHEMBL4984247 | 0.67 | CDK2 (0.53) | MAPTNPC1KDM4EGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115916747-A | Fused heterocyclic derivative and application thereof in medicine | 四川海思科制药有限公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-111362975-B | Naphthyridine compounds as JAK kinase inhibitors | 施万生物制药研发IP有限责任公司 | 2022-04-05 | — | — | CN | disclosed |
| CN-111362975-A | Naphthyridine compounds as JAK kinase inhibitors | 施万生物制药研发IP有限责任公司 | 2020-07-03 | — | — | CN | disclosed |
| CN-107667108-B | Naphthyridine compounds as JAK kinase inhibitors | 施万生物制药研发IP有限责任公司 | 2020-05-12 | — | — | CN | disclosed |