Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | C1S | P09871 | 2/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
| ▸ | ILK | Q13418 | 2/20 | 0.31 |
| ▸ | DHFR | P00374 | 2/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL29566493 | 1.00 | MAPT (0.37) | MAPTNPC1L3MBTL1KDM4EGAA | |
| Trifluoroacetic Acid SCHEMBL28416274 | 1.00 | MAPT (0.37) | MAPTNPC1L3MBTL1KDM4EGAA | |
| SCHEMBL29565779 | 0.88 | MAPT (0.44) | MAPTNPC1L3MBTL1KDM4EGAA | |
| SCHEMBL28411462 | 0.88 | MAPT (0.44) | MAPTNPC1L3MBTL1KDM4EGAA | |
| Hydrochloric Acid SCHEMBL28411373 | 0.87 | MAPT (0.43) | MAPTNPC1L3MBTL1KDM4EGAA | |
| Hydrochloric Acid SCHEMBL29565430 | 0.87 | MAPT (0.43) | MAPTNPC1L3MBTL1KDM4EGAA | |
| Trifluoroacetic Acid SCHEMBL29565798 | 0.67 | TYK2 (0.50) | GSK3AGSK3B | |
| SCHEMBL28300570 | 0.65 | CYP1A1 (0.52) | NPC1L3MBTL1KDM4EGAAHSD17B10 | |
| SCHEMBL14596555 | 0.64 | DHFR (0.54) | MAPTNPC1KDM4EHSD17B10DHFR | |
| Trifluoroacetic Acid SCHEMBL30452000 | 0.60 | C1S (0.43) | MAPTNPC1L3MBTL1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111362975-B | Naphthyridine compounds as JAK kinase inhibitors | 施万生物制药研发IP有限责任公司 | 2022-04-05 | — | — | CN | disclosed |