Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Cholesterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OSBP | P22059 | 4/20 | 0.84 |
| ▸ | RORC | P51449 | 4/20 | 0.84 |
| ▸ | OSBP2 | Q969R2 | 2/20 | 0.84 |
| ▸ | USP2 | O75604 | 1/20 | 0.84 |
| ▸ | LMNA | P02545 | 1/20 | 0.84 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.84 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.84 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.73 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.73 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.73 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.73 |
| ▸ | NPC1L1 | Q9UHC9 | 3/20 | 0.69 |
| ▸ | CRYAB | P02511 | 1/20 | 0.69 |
| ▸ | HMGCR | P04035 | 1/20 | 0.69 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.69 |
| ▸ | ITGAV | P06756 | 1/20 | 0.69 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.69 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.68 |
| ▸ | POLA1 | P09884 | 1/20 | 0.68 |
| ▸ | DHCR24 | Q15392 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cholesterol SCHEMBL10379192 | 0.99 | OSBP (0.86) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL19583430 | 0.99 | OSBP (0.86) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL19583433 | 0.99 | OSBP (0.86) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL10379694 | 0.95 | OSBP (0.79) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL27833163 | 0.95 | OSBP (0.82) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL27631455 | 0.94 | OSBP (0.86) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL29502101 | 0.94 | OSBP (0.93) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL27668883 | 0.94 | OSBP (0.93) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL1369602 | 0.94 | OSBP (0.93) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL29046878 | 0.93 | OSBP (0.79) | OSBPRORCOSBP2USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107652987-B | Preparation method of maleic acid cholesterol monoester group citric acid triester liquid crystal | 太原理工大学 | 2020-06-23 | — | — | CN | claimed |
| CN-107652987-B | Preparation method of maleic acid cholesterol monoester group citric acid triester liquid crystal | 太原理工大学 | 2020-06-23 | — | — | CN | disclosed |