Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 4/20 | 0.47 |
| ▸ | AXL | P30530 | 4/20 | 0.47 |
| ▸ | MERTK | Q12866 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.43 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30448414 | 0.85 | AXL (0.48) | METAXLMERTKBRAFHDAC1 | |
| SCHEMBL28408407 | 0.82 | KDM4E (0.39) | METAXLMERTKBRAFHDAC1 | |
| SCHEMBL28850304 | 0.80 | HIPK4 (0.64) | METAXLMERTKBRAFHDAC1 | |
| SCHEMBL6049774 | 0.79 | ALDH1A1 (0.46) | BRAFHDAC1KMT2ARAB9ANPC1 | |
| SCHEMBL30448108 | 0.77 | RAB9A (0.46) | BRAFHDAC1KMT2ARAB9ANPC1 | |
| SCHEMBL30448073 | 0.76 | KMT2A (0.51) | BRAFHDAC1KMT2ARAB9ANPC1 | |
| SCHEMBL4265602 | 0.75 | NAMPT (0.48) | KMT2ARAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL4252286 | 0.74 | MEN1 (0.45) | BRAFHDAC1KMT2ASMN1; SMN2KDR | |
| SCHEMBL29614703 | 0.74 | MEN1 (0.45) | BRAFHDAC1KMT2ASMN1; SMN2KDR | |
| SCHEMBL5568329 | 0.71 | RAF1 (0.64) | METAXLMERTKBRAFKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107129465-B | Aryl guanidine compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2020-06-19 | — | — | CN | disclosed |