Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GCG | P01275 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211142 | 0.91 | CTSK (0.42) | CTSKNOTUMKDM4EALDH1A1MTOR | |
| SCHEMBL211143 | 0.91 | CTSK (0.42) | CTSKNOTUMKDM4EALDH1A1MTOR | |
| SCHEMBL10278482 | 0.88 | CTSK (0.45) | CTSKNOTUMKDM4EALDH1A1MTOR | |
| SCHEMBL9606798 | 0.85 | NOTUM (0.47) | CTSKNOTUMKDM4EALDH1A1MTOR | |
| SCHEMBL215046 | 0.81 | ALDH1A1 (0.48) | CTSKNOTUMKDM4EALDH1A1MTOR | |
| SCHEMBL213835 | 0.80 | KDM4E (0.47) | CTSKNOTUMKDM4EALDH1A1MTOR | |
| SCHEMBL213605 | 0.79 | KDM4E (0.46) | NOTUMKDM4EALDH1A1EGLN1WNT3A | |
| SCHEMBL14733483 | 0.79 | NOTUM (0.41) | CTSKNOTUMKDM4EALDH1A1GCG | |
| SCHEMBL210115 | 0.79 | MAP4K1 (0.46) | NOTUMWNT3AMAPK1 | |
| SCHEMBL210114 | 0.79 | MAP4K1 (0.46) | NOTUMWNT3AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195328-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Incorporated (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009023193-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2009-02-19 | — | — | WO | disclosed |