SCHEMBL28417237

SCHEMBL28417237

C/C(=C(/C#N)C(=O)c1ccccc1)c1ccc(C)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 8/20 0.59
CES1 P23141 8/20 0.59
RAB9A P51151 4/20 0.55
ALDH1A1 P00352 4/20 0.55
MAPT P10636 3/20 0.55
LMNA P02545 2/20 0.55
XBP1 P17861 1/20 0.55
MAPK1 P28482 1/20 0.55
NPSR1 Q6W5P4 1/20 0.55
NPC1 O15118 3/20 0.46
KMT2A Q03164 2/20 0.46
MEN1 O00255 1/20 0.46
HPGD P15428 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
POLB P06746 1/20 0.42
VCP P55072 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
AKR1C3 P42330 1/20 0.40
EGFR P00533 1/20 0.40
ERBB2 P04626 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28892760 0.92 ALDH1A1 (0.64) CES2CES1RAB9AALDH1A1MAPT
SCHEMBL28425331 0.86 ALDH1A1 (0.54) CES2CES1RAB9AALDH1A1MAPT
SCHEMBL28424518 0.83 CES2 (0.63) CES2CES1RAB9AALDH1A1MAPT
SCHEMBL11339856 0.83 CES2 (0.54) CES2CES1RAB9AALDH1A1MAPT
SCHEMBL11558620 0.83 CES2 (0.54) CES2CES1RAB9AALDH1A1MAPT
SCHEMBL9447416 0.83 ALDH1A1 (0.47) CES2CES1RAB9AALDH1A1MAPT
SCHEMBL9447417 0.83 ALDH1A1 (0.47) CES2CES1RAB9AALDH1A1MAPT
SCHEMBL28968054 0.80 RAB9A (0.51) CES2CES1RAB9AALDH1A1MAPT
SCHEMBL12588773 0.79 ALDH1A1 (0.66) CES2CES1RAB9AALDH1A1MAPT
SCHEMBL11341276 0.79 ALDH1A1 (0.66) CES2CES1RAB9AALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111393322-B Cyclization synthesis method of naphthalocyanide and derivative thereof 石河子大学 2023-03-17 CN disclosed
CN-111393322-A Cyclization synthesis method of naphthalocyanide and derivative thereof 石河子大学 2020-07-10 CN disclosed