Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | POLQ | O75417 | 1/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.40 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 3/20 | 0.40 |
| ▸ | SCD | O00767 | 3/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28415697 | 0.87 | CREBBP (0.58) | CREBBPEP300BRD2BRD3EPHB3 | |
| SCHEMBL28411099 | 0.86 | KDM4E (0.44) | CREBBPKDM4EALDH1A1EP300BRD2 | |
| SCHEMBL28410723 | 0.86 | CREBBP (0.45) | CREBBPKDM4EEP300BRD2BRD3 | |
| SCHEMBL28881183 | 0.85 | CREBBP (0.64) | CREBBPPOLQEP300BRD2BRD3 | |
| SCHEMBL28415713 | 0.85 | CREBBP (0.46) | CREBBPEP300BRD2BRD3EPHB3 | |
| SCHEMBL28417785 | 0.83 | CREBBP (0.44) | CREBBPEP300BRD2BRD3EPHB3 | |
| SCHEMBL28413189 | 0.83 | CREBBP (0.58) | CREBBPEP300BRD2BRD3EPHB3 | |
| SCHEMBL28416810 | 0.83 | ABCB1 (0.45) | CREBBPKDM4EALDH1A1BRD2BRD3 | |
| SCHEMBL28891091 | 0.80 | CREBBP (0.41) | CREBBPKDM4EEP300BRD2BRD3 | |
| SCHEMBL28418305 | 0.79 | CREBBP (0.43) | CREBBPEP300BRD2BRD3EPHB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111320621-A | Indolizine compound and preparation method and application thereof | 中国科学院广州生物医药与健康研究院 | 2020-06-23 | — | — | CN | disclosed |