Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 4/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 6/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 3/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 1/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28417785 | 0.92 | CREBBP (0.44) | ABCB1CREBBPATRBRD2BRD3 | |
| SCHEMBL28411099 | 0.90 | KDM4E (0.44) | CREBBPBRD2BRD3SMN1; SMN2ALDH1A1 | |
| SCHEMBL28415697 | 0.87 | CREBBP (0.58) | CREBBPBRD2BRD3 | |
| SCHEMBL28891091 | 0.85 | CREBBP (0.41) | CREBBPBRD2BRD3SMN1; SMN2KDM4E | |
| SCHEMBL28415713 | 0.85 | CREBBP (0.46) | CREBBPBRD2BRD3SMN1; SMN2DYRK1A | |
| SCHEMBL28418185 | 0.84 | CREBBP (0.40) | CREBBPCYP17A1CYP11B1CYP11B2BRD2 | |
| SCHEMBL28418305 | 0.84 | CREBBP (0.43) | CREBBPATRBRD2BRD3SMN1; SMN2 | |
| SCHEMBL28413189 | 0.84 | CREBBP (0.58) | CREBBPBRD2BRD3 | |
| SCHEMBL28410723 | 0.83 | CREBBP (0.45) | CREBBPBRD2BRD3KDM4E | |
| SCHEMBL28422565 | 0.82 | LCLAT1 (0.40) | CREBBPSMN1; SMN2ALDH1A1KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111320621-A | Indolizine compound and preparation method and application thereof | 中国科学院广州生物医药与健康研究院 | 2020-06-23 | — | — | CN | disclosed |