Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | NOS1 | P29475 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | KDM4B | O94953 | 1/20 | 0.46 |
| ▸ | KDM5C | P41229 | 1/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzamide SCHEMBL3177602 | 0.84 | PARP1 (0.55) | HSD17B10TSHRPOLBCYP3A4PARP1 | |
| Benzamide SCHEMBL4367079 | 0.83 | HSD17B10 (0.53) | HSD17B10TSHRPOLBCYP3A4PARP1 | |
| 2-Phenylthiazole SCHEMBL5968560 | 0.81 | PDPK1 (0.68) | HSD17B10TSHRPOLBCYP3A4PARP1 | |
| Aminothiazole SCHEMBL1241596 | 0.80 | ALDH1A1 (0.75) | HSD17B10TSHRMAPTRECQLL3MBTL1 | |
| Benzamide SCHEMBL27660453 | 0.78 | PARP1 (0.94) | HSD17B10TSHRPOLBCYP3A4PARP1 | |
| Aminothiazole SCHEMBL6051173 | 0.78 | ALDH1A1 (0.88) | HSD17B10TSHRCYP3A4CYP2C19BLM | |
| Aminothiazole SCHEMBL27899272 | 0.78 | — | — | |
| Biphenyl SCHEMBL28794521 | 0.77 | ALDH1A1 (0.68) | HSD17B10TSHRCYP3A4MAPTTDP1 | |
| Aminothiazole SCHEMBL1003511 | 0.77 | ALDH1A1 (0.68) | HSD17B10TSHRMAPTRECQLL3MBTL1 | |
| Aminothiazole SCHEMBL4466019 | 0.77 | ALDH1A1 (0.68) | HSD17B10TSHRMAPTRECQLL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017066225-A1 | PHARMACOPERONES OF THE V2 RECEPTOR | TEXAS TECH UNIVERSITY SYSTEM (US) | 2017-04-20 | — | — | WO | claimed |
| CN-109320473-A | Thiazoleamino benzamide acetogenin and application thereof | 南华大学 | 2019-02-12 | — | — | CN | disclosed |
| CN-109320473-A | Thiazoleamino benzamide acetogenin and application thereof | 南华大学 | 2019-02-12 | — | — | CN | disclosed |
| CN-109320473-A | Thiazoleamino benzamide acetogenin and application thereof | 南华大学 | 2019-02-12 | — | — | CN | disclosed |
| WO-2017066225-A1 | PHARMACOPERONES OF THE V2 RECEPTOR | TEXAS TECH UNIVERSITY SYSTEM (US) | 2017-04-20 | — | — | WO | disclosed |
| US-20140179711-A1 | PROCESS FOR PREPARING 2-AMINOTHIAZOLE-5-AROMATIC CARBOXAMIDES AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-06-26 | — | — | US | disclosed |
| US-8680103-B2 | Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-03-25 | — | — | US | disclosed |
| EP-1711481-B2 | CRYSTALLINE MONOHYDRATE AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2013-05-22 | — | — | EP | disclosed |
| US-20120302750-A1 | PROCESS FOR PREPARING 2-AMINOTHIAZOLE-5-AROMATIC CARBOXAMIDES AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2012-11-29 | — | — | US | disclosed |
| US-8242270-B2 | Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-08-14 | — | — | US | disclosed |
| EP-1594866-A1 | ANTIPROLIFERATIVE 2-(SULFO-PHENYL)-AMINOTHIAZOLE DERIVATIVES | PFIZER INC. (US) | 2005-11-16 | — | — | EP | disclosed |
| US-20050215795-A1 | Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2005-09-29 | — | — | US | disclosed |
| WO-2005077945-A2 | PROCESS FOR PREPARING 2-AMINOTHIAZOLE-5-AROMATIC CARBOXAMIDES AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-08-25 | — | — | WO | disclosed |
| WO-2005076990-A2 | PROCESS FOR PREPARING 2-AMINOTHIAZOLE-5-CARBOXAMIDES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-08-25 | — | — | WO | disclosed |
| US-20050176965-A1 | Process for preparing 2-aminothiazole-5-carboxamides useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2005-08-11 | — | — | US | disclosed |
| US-20050176773-A1 | Antiproliferative 2-(heteroaryl)-aminothiazole compounds and pharmaceutical compositions, and method for their use | AGOURON PHARMACEUTICALS, INC. | 2005-08-11 | — | — | US | disclosed |
| US-20050038078-A1 | Antiproliferative 2-(heteroaryl)-aminothiazole compounds and pharmaceutical compositions, and methods for their use | AGOURON PHARMACEUTICALS, INC. | 2005-02-17 | — | — | US | disclosed |
| US-20040176431-A1 | Antiproliferative 2-(sulfo-phenyl)-aminothiazole derivatives and pharmaceutical compositions, and methods for their use | PFIZER, INC. | 2004-09-09 | — | — | US | disclosed |
| WO-2004072070-A1 | ANTIPROLIFERATIVE 2-(SULFO-PHENYL)-AMINOTHIAZOLE DERIVATIVES | PFIZER INC. (US) | 2004-08-26 | — | — | WO | disclosed |
| WO-2004014904-A1 | ANTIPROLIFERATIVE 2-(HETEROARYL)-AMINOTHIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USE | PFIZER INC. (US) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120302750-A1 | PROCESS FOR PREPARING 2-AMINOTHIAZOLE-5-AROMATIC CARBOXAMIDES AS KINASE INHIBITORS | MAP3K5, MAP3K2, MAP3K20 | HSD17B10 2868/4885TSHR 995/4885POLB 4131/4885 |
| US-20050215795-A1 | Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors | MAP3K5, MAP3K2, MAP3K20 | HSD17B10 2868/4885TSHR 995/4885POLB 4131/4885 |
| US-20050176773-A1 | Antiproliferative 2-(heteroaryl)-aminothiazole compounds and pharmaceutical compositions, and method for their use | CDK2, MKI67, CCNK | HSD17B10 2047/4885TSHR 3589/4885POLB 749/4885 |
| US-20050176965-A1 | Process for preparing 2-aminothiazole-5-carboxamides useful as kinase inhibitors | CDK2, MAP3K5, MAP4K2 | HSD17B10 3846/4885TSHR 1144/4885POLB 3235/4885 |
| US-20050038078-A1 | Antiproliferative 2-(heteroaryl)-aminothiazole compounds and pharmaceutical compositions, and methods for their use | CDK2, CCNK, MKI67 | HSD17B10 2277/4885TSHR 3823/4885POLB 885/4885 |
| US-20140179711-A1 | PROCESS FOR PREPARING 2-AMINOTHIAZOLE-5-AROMATIC CARBOXAMIDES AS KINASE INHIBITORS | MAP3K5, MAP3K2, MAP3K20 | HSD17B10 2868/4885TSHR 995/4885POLB 4131/4885 |
| US-20040176431-A1 | Antiproliferative 2-(sulfo-phenyl)-aminothiazole derivatives and pharmaceutical compositions, and methods for their use | MKI67, TK1, CDK2 | HSD17B10 2308/4885TSHR 2697/4885POLB 1792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.