Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.41 |
| ▸ | FDPS | P14324 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.40 |
| ▸ | ABAT | P80404 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3923554 | 0.83 | ALDH1A1 (0.42) | ALDH1A1TSHRHPGDMEN1POLB | |
| SCHEMBL3673596 | 0.83 | ALDH1A1 (0.57) | ALDH1A1TSHRHPGDMEN1KMT2A | |
| SCHEMBL30360257 | 0.83 | ALDH1A1 (0.57) | ALDH1A1TSHRHPGDMEN1KMT2A | |
| SCHEMBL3689377 | 0.81 | ALDH1A1 (0.43) | ALDH1A1TSHRHPGDMEN1POLB | |
| SCHEMBL7531959 | 0.79 | ALDH1A1 (0.68) | ALDH1A1TSHRHPGDMEN1POLB | |
| SCHEMBL29400600 | 0.79 | ALDH1A1 (0.68) | ALDH1A1TSHRHPGDMEN1POLB | |
| SCHEMBL435689 | 0.79 | ALDH1A1 (0.68) | ALDH1A1TSHRHPGDMEN1POLB | |
| SCHEMBL9677313 | 0.79 | ALDH1A1 (0.72) | ALDH1A1TSHRHPGDMEN1KMT2A | |
| SCHEMBL14033967 | 0.75 | ALDH1A3 (0.52) | ALDH1A1TSHRHPGDMEN1POLB | |
| SCHEMBL2585951 | 0.75 | ALDH1A1 (0.60) | ALDH1A1TSHRHPGDMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111285874-A | RET inhibitors, pharmaceutical compositions thereof and uses thereof | 广东东阳光药业有限公司 | 2020-06-16 | — | — | CN | disclosed |
| CN-111285873-A | RET inhibitors, pharmaceutical compositions thereof and uses thereof | 广东东阳光药业有限公司 | 2020-06-16 | — | — | CN | disclosed |