Sugi Predict

Sugi Predict / Compounds / Glycine

Glycine

Glycine

SCHEMBL2842691

NCC(=O)O.N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D

The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ PDE4A known ✓ P27815 1/20 0.44
▸ USP2 O75604 1/20 0.50
▸ SLCO1B1 Q9Y6L6 1/20 0.50
▸ PAX8 Q06710 1/20 0.42
▸ LMNA P02545 2/20 0.41
▸ L3MBTL1 Q9Y468 1/20 0.41
▸ TDP1 Q9NUW8 1/20 0.39
▸ GLRA1 P23415 1/20 0.37
▸ SLC6A9 P48067 1/20 0.37
▸ OR51E2 Q9H255 1/20 0.37
▸ AKR1B1 P15121 1/20 0.32
▸ KDM4E B2RXH2 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bicarbonate SCHEMBL20888 0.90 USP2 (0.55) USP2SLCO1B1PDE4APAX8LMNA
Dimethyl Sulfone SCHEMBL16650660 0.89 USP2 (0.41) USP2SLCO1B1PDE4APAX8LMNA
Malonic Acid SCHEMBL5866696 0.89 USP2 (0.50) USP2SLCO1B1PDE4APAX8LMNA
Succinic Acid SCHEMBL17748517 0.89 USP2 (0.50) USP2SLCO1B1PDE4APAX8LMNA
Succinic Acid SCHEMBL722957 0.89 USP2 (0.50) USP2SLCO1B1PDE4APAX8LMNA
Malonic Acid SCHEMBL17748563 0.89 USP2 (0.50) USP2SLCO1B1PDE4APAX8LMNA
Acetic Acid SCHEMBL7572044 0.89 USP2 (0.53) USP2SLCO1B1PDE4APAX8LMNA
Acetic Acid SCHEMBL403998 0.89 USP2 (0.53) USP2SLCO1B1PDE4APAX8LMNA
Acetic Acid SCHEMBL8370700 0.89 USP2 (0.53) USP2SLCO1B1PDE4APAX8LMNA
Acetic Acid SCHEMBL489053 0.89 USP2 (0.53) USP2SLCO1B1PDE4APAX8LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010017403-A9 THERAPEUTIC COMPOSITIONS, DEVICES AND METHODS FOR OBSERVING TREATED TISSUES IMMUNOPATH PROFILE, INC. (US) 2010-11-04 — — WO disclosed
WO-2010017403-A2 THERAPEUTIC COMPOSITIONS, DEVICES AND METHODS FOR OBSERVING TREATED TISSUES IMMUNOPATH PROFILE, INC. (US) 2010-02-11 — — WO disclosed
US-20090324489-A1 Wortmannin conjugates and uses thereof BETH ISRAEL DEACONESS MEDICAL CENTER 2009-12-31 — — US disclosed
EP-1940386-A2 WORTMANNIN CONJUGATES AND USES THEREOF Beth Israel Deaconess Medical Center (US) 2008-07-09 — — EP disclosed
WO-2007086943-A2 WORTMANNIN CONJUGATES AND USES THEREOF BETH ISRAEL DEACONESS MEDICAL CENTER (US) 2007-08-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090324489-A1 Wortmannin conjugates and uses thereof PIK3CG, PIK3C3, PIK3CA PDE4A 2736/4885USP2 2426/4885SLCO1B1 4205/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.