Malonic Acid

Malonic Acid

SCHEMBL5866696

N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO.O=C(O)CC(=O)O

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
USP2 O75604 1/20 0.50
SLCO1B1 Q9Y6L6 1/20 0.50
PAX8 Q06710 1/20 0.46
PDE4A P27815 1/20 0.44
LMNA P02545 2/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
TDP1 Q9NUW8 1/20 0.39
KDM4E B2RXH2 2/20 0.35
LDHA P00338 1/20 0.33
SRR Q9GZT4 1/20 0.33
AKR1B1 P15121 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Malonic Acid SCHEMBL17748563 1.00 USP2 (0.50) USP2SLCO1B1PAX8PDE4ALMNA
Bicarbonate SCHEMBL20888 0.90 USP2 (0.55) USP2SLCO1B1PAX8PDE4ALMNA
Glycine SCHEMBL2842691 0.89 USP2 (0.50) USP2SLCO1B1PAX8PDE4ALMNA
Succinic Acid SCHEMBL17748517 0.89 USP2 (0.50) USP2SLCO1B1PAX8PDE4ALMNA
Succinic Acid SCHEMBL722957 0.89 USP2 (0.50) USP2SLCO1B1PAX8PDE4ALMNA
Acetic Acid SCHEMBL7572044 0.89 USP2 (0.53) USP2SLCO1B1PAX8PDE4ALMNA
Acetic Acid SCHEMBL489053 0.89 USP2 (0.53) USP2SLCO1B1PAX8PDE4ALMNA
Acetic Acid SCHEMBL8370700 0.89 USP2 (0.53) USP2SLCO1B1PAX8PDE4ALMNA
Acetic Acid SCHEMBL403998 0.89 USP2 (0.53) USP2SLCO1B1PAX8PDE4ALMNA
SCHEMBL2227363 0.88 LMNA (0.52) USP2SLCO1B1PAX8PDE4ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10813868-B2 Method of improving hair volume CONOPCO, INC. (US) 2020-10-27 US disclosed
EP-3218062-B1 METHOD OF IMPROVING HAIR VOLUME UNILEVER PLC (GB) 2019-09-18 EP disclosed
US-20170333328-A1 METHOD OF IMPROVING HAIR VOLUME CONOPCO, INC., D/B/A UNILEVER (US) 2017-11-23 US disclosed
EP-3218062-A1 METHOD OF IMPROVING HAIR VOLUME Unilever PLC (GB) 2017-09-20 EP disclosed
WO-2016074966-A1 METHOD OF IMPROVING HAIR VOLUME UNILEVER PLC (GB) 2016-05-19 WO disclosed
US-20060142207-A1 Compositions and methods for treating cancer THRESHOLD PHARMACEUTICALS, INC. (US) 2006-06-29 US disclosed
US-7001888-B2 Compositions and methods for treating cancer THRESHOLD PHARMACEUTICALS, INC. (US) 2006-02-21 US disclosed
US-20040029815-A1 Compositions and methods for treating cancer THRESHOLD PHARMACEUTICALS, INC. 2004-02-12 US disclosed
WO-2003082301-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER THRESHOLD PHARMACEUTICALS, INC. (US) 2003-10-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170333328-A1 METHOD OF IMPROVING HAIR VOLUME NACA, FTH1, FSCN1 USP2 3163/4885SLCO1B1 851/4885PAX8 1173/4885
US-20040029815-A1 Compositions and methods for treating cancer SLC2A2, SLC2A1, SLC2A3 USP2 2518/4885SLCO1B1 134/4885PAX8 1966/4885
US-10813868-B2 Method of improving hair volume NACA, FTH1, FSCN1 USP2 3163/4885SLCO1B1 851/4885PAX8 1173/4885
US-20060142207-A1 Compositions and methods for treating cancer SLC2A2, SLC2A1, SLC2A3 USP2 2518/4885SLCO1B1 134/4885PAX8 1966/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.