Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 10/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GCG | P01275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28707601 | 0.81 | ALDH1A1 (0.35) | EGLN1KMT2AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL28535799 | 0.78 | GCGR (0.45) | ALDH1A1KDM4EGCG | |
| SCHEMBL28938106 | 0.76 | EGLN1 (0.43) | EGLN1ALDH1A1 | |
| SCHEMBL23957696 | 0.76 | EGLN1 (0.43) | EGLN1ALDH1A1 | |
| SCHEMBL12989502 | 0.75 | EGLN1 (0.47) | EGLN1 | |
| SCHEMBL28938099 | 0.74 | EGLN1 (0.40) | EGLN1ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL28236753 | 0.72 | KDM4E (0.54) | RAB9AKMT2AALDH1A1CYP1A2HPGD | |
| SCHEMBL15739713 | 0.72 | LMNA (0.46) | KMT2AALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL23957800 | 0.72 | KCNJ1 (0.56) | EGLN1KMT2A | |
| SCHEMBL23929975 | 0.72 | EGLN1 (0.45) | EGLN1ALDH1A1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423416-B | Inhibitors of RET | 缆图药品公司 | 2023-05-26 | — | — | CN | disclosed |
| CN-111423416-A | Inhibitors of RET | 蓝图药品公司 | 2020-07-17 | — | — | CN | disclosed |
| CN-108473468-B | Inhibitors of RET | 蓝图药品公司 | 2020-06-16 | — | — | CN | disclosed |