Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2846692 | 0.90 | L3MBTL1 (0.62) | TSHRALDH1A1GAA | |
| SCHEMBL2842887 | 0.89 | TSHR (0.59) | TSHRALDH1A1TP53GAA | |
| SCHEMBL2847484 | 0.88 | L3MBTL1 (0.59) | TSHRALDH1A1GAA | |
| SCHEMBL2837131 | 0.86 | L3MBTL1 (0.56) | TSHRALDH1A1GAA | |
| SCHEMBL13381505 | 0.85 | TSHR (0.60) | TSHRALDH1A1TP53KDM4ELMNA | |
| SCHEMBL2842383 | 0.84 | L3MBTL1 (0.56) | TSHRALDH1A1GAA | |
| SCHEMBL2846591 | 0.84 | L3MBTL1 (0.66) | TSHRALDH1A1GAA | |
| SCHEMBL2841062 | 0.84 | L3MBTL1 (0.66) | TSHRALDH1A1KDM4EPOLBGAA | |
| SCHEMBL2838490 | 0.83 | L3MBTL1 (0.53) | TSHRALDH1A1GAA | |
| SCHEMBL2843771 | 0.83 | ALDH1A1 (0.62) | TSHRALDH1A1TP53KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039911-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | claimed |
| WO-2010039911-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |
| WO-2010039911-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |